Nanoemulsion is an alternative and promising approach to overcome insolubility and bioavailability problems of bioactive compounds. In this study, the sonication parameter for preparing nanoemulsions with high α- tocopherol and linolenic acid content were optimized by using response surface methodology and their stability were evaluated during 2 months’ storage. The response surface analysis re...

Abstract Hydroxycitronellal has been widely used in foods, beverages, perfumery and cosmetics. It can also be to treat anxiety. The major drawbacks regarding the use of hydroxycitronellal are related water insolubility, volatility, instability, sensitization. To overcome these concerns, β-cyclodextrin was adopted as wall material encapsulate this work. Hydroxycitronellal-β-cyclodextrin inclusio...

Albendazole is an anti-helmintic or anti-worm medication. Due to its water insolubility, it shows poor absorption in GIT as well low bioavailability and produces therapeutic effect. In this study, various hydrotropic agents are used enhance the solubility of Albendazole. Addition 100mg 1M Solution agent like Sodium benzoate, acetate, citrate, salicylate & urea separately absorbance each sol...

Insolubility of functional molecules caused by polymorphism sometimes poses limitations for their solution‐based processing. Such a situation can also occur in the preparation processes supramolecular polymers formed solution. An effective strategy to address this issue is prepare amorphous solid states introducing “coformer” molecule capable inhibiting formation an insoluble polymorph through ...

A diverse set of cell surface eukaryotic proteins including receptors, enzymes, and adhesion molecules have a glycosylphosphoinositol-lipid (GPI) modification at the carboxy-terminal end that serves as their sole means of membrane anchoring. These GPI-anchored proteins are poorly solubilized in nonionic detergent such as Triton X-100. In addition these detergent-insoluble complexes from plasma ...