There has been an increased demand for the development of novel vaccine adjuvants that lead to enhanced induction of protection from infectious challenges and development of immunological memory. A novel vaccine adjuvant was developed comprising a complex containing CpG oligonucleotide and the synthetic cationic innate defence regulator peptide HH2 that has enhanced immune modulating activities...

Hepcidin is an innate immune element which decreases the iron absorption from diet and iron releasing from macrophage cell. In contrast to the chemical iron chelators, there has been limited effort applied to the specific use of hepcidin as a new drug for decreasing the iron overload. Hepcidin is produced in different biological systems. For instance, E-coli is used for human hepcidin expressio...

The problem of acquiring language is a difficult and complex one. The traditional assumption is that infants acquire language by virtue of innate knowledge, which reduces the problem to one of tuning this innate knowledge of language in general, to the specific characteristics of the language spoken in the infant’s early environment (e.g. Chomsky, 1980). Nevertheless, without empirical assessme...

Although linguistic nativism has received the bulk of attention in contemporary innateness debates, moral nativism has perhaps an even deeper ancestry. If linguistic nativism is Cartesian, moral nativism is Platonic. Moral nativism has taken a backseat to linguistic nativism in contemporary discussions largely because Chomsky made a case for linguistic nativism characterized by unprecedented ri...

What kinds of knowledge underlie the use of language and how is this knowledge acquired? Linguists equate knowing a language with knowing a grammar. Classic "poverty of the stimulus" arguments suggest that grammar identification is an intractable inductive problem and that acquisition is possible only because children possess innate knowledge of grammatical structure. An alternative view is eme...

Novel and more effective immunization strategies against many animal diseases may profit from the current knowledge on the modulation of specific immunity through stimulation of innate immune receptors. Toll-like receptor (TLR)2-targeting formulations, such as synthetic lipopeptides and antigens expressed in fusion with lipoproteins, have been shown to have built-in adjuvant properties and to b...

RIG-I and MDA5 are cytosolic RNA sensors that play a critical role in innate antiviral responses. Major advances have been made in identifying RIG-I ligands, but our knowledge of the ligands for MDA5 remains restricted to data from transfection experiments mostly using poly(I:C), a synthetic dsRNA mimic. Here, we dissected the IFN-α/β-stimulatory activity of different viral RNA species produced...

The algorithmic generation of textual descriptions of real world image sequences requires conceptual knowledge. The algorithmic generation of synthetic image sequences from textual descriptions requires conceptual knowledge, too. An explicit representation formalism for behavioral knowledge based on formal logic is presented which can be utilized in both tasks – Understanding and Creation of vi...

This study describes a discourse approach to explanation aware knowledge representation. It presents a reasoning model that adheres to argumentation as found in written discourse, intended for use in intelligent human-computer collaboration and inter-agent deliberation. The approach integrates the Toulmin model with Rhetorical Structure Theory and Perelman and Olbrechts-Tyteca’s (1958) strategi...