BACKGROUND Inhalational insulin was withdrawn from market in 2007 due to its potential to produce airway hyper-reactivity and bronchoconstriction. So we explored the possible mechanism underlying the acute contractile effects of insulin and protective effects of beclomethasone against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pig in vitro. METHOD...

BACKGROUND Systemic corticosteroids are known to increase diabetes risk, but the effects of high-dose inhaled corticosteroids are unknown. We assessed whether the use and dose of inhaled corticosteroids increase the risk of diabetes onset and progression. METHODS We formed a new-user cohort of patients treated for respiratory disease during 1990-2005, identified using the Quebec health insura...

Aim use of inhalational insulin was limited due to its high cost and its potential to produce respiratory adverse effects. So current study was designed to evaluate the acute effects of insulin on airway reactivity and protective effects of salbutamol and ipratropium against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pig. Material and methods: effec...

Early lung cancer detection may save lives but is controversial [1]. Recently a study appeared documenting improved survival of early lung cancer detected with spiral CT [2]. Biochemical methods of early lung cancer detection have been developed. For example, measurement of an autoantibody response to one or more tumor-associated antigens in an optimized panel assay provides a sensitive and spe...

Type 2 diabetes mellitus (DM) and dementia are two conditions highly prevalent today and probably interrelated. The term type 3 diabetes has therefore been proposed to try and provide a view integrating the potential pathogenetic mechanisms shared by DM and Alzheimer disease (AD). Significant epidemiological evidence relating DM and dementia has accumulated in the past decade. According to a re...