Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract comprising Crohn's disease and ulcerative colitis. Although the pathogenesis of the disease is not clearly defined yet, environmental, genetic and other factors contribute to the onset of the disease. Apart from the clinical and histopathological findings, several serological biomarkers are also em...

Background & Objective: Inflammatory bowel diseases (IBDs) represent serious chronic auto-inflammatory conditions, affecting the alimentary tract. The beneficial effect of dexpanthenol has been observed on some inflammatory conditions. Here, the therapeutic potential of combined dexpanthenol and prednisolone in alleviating the symptoms of the animal model of IBD was investigated. Materials & M...

Abstract Inflammatory bowel disease (IBD) is a class of chronic disorders whose etiogenesis still unknown. Despite the high number IBD-related omics studies, RNA-sequencing data produced results that are hard to compare because experimental variability and different analysis approaches. We here introduce IBD Transcriptome Metatranscriptome Meta-Analysis (TaMMA) framework, comprehensive survey p...

Inflammatory bowel disease (IBD) frequently affects young patients of childbearing age. Treatments for inflammatory bowel disease include immunosuppressive, cytotoxic and surgical therapies. Azathioprine is frequently used to treat patients with steroid dependent IBD. We report the case of a patient with ulcerative colitis, treated with azathioprine prior to conception and during the subsequent...

Interest in inflammatory bowel disease (IBD) has been increasing for the past 20 years, and the clinical features have been well defined.15 The importance of determining the long-term prognosis has been emphasized as a result of the increasing incidence of IBD, particularly Crohn’s disease,4 and the significant percentage of adolescent patients.3,4,6,7 Because of the nature of IBD and the relat...

Objective: To find out the prevalence of Human Leucocyte Antigen B27 (HLA-B27) in inflammatory bowel disease patients in Jordan. Methods: Over the last year (2005) all inflammatory bowel disease (IBD) patients attending the gastroenterology outpatient clinic at King Hussein Medical Center(KHMC), were given a questionnaire asking them to report back pain and the characteristics of this pain. The...

the peak age of onset of inflammatory bowel disease (ibd) is simultaneous with the peak reproductive years. patients have many concerns about the impact of ibd on fertility and pregnancy outcomes. the most important reason for voluntary childlessness is the fear of side effects from medications for ibd. decision making for medical therapy is a complex equation. it is important to summarize avai...

inflammatory bowel disease (ibd) is the term used for a group of diseases with yet unknown etiology, prevalence of which is increasing almost everywhere in the world. the disease was almost non-existent four decades ago in the east, including the middle-east, while now a days it is seen more and more. in addition to the increasing prevalence, our knowledge about its pathogenesis, clinical cours...

ulcerative colitis and crohn's disease are chronic, relapsing, inflammatory conditions defined by their phenotypic features. family studies have identified a clear genetic influence on disease susceptibility and expression. molecular studies have identified specific genes that predispose individuals to the development of inflammatory bowel disease. some of these genes are specific to either ulc...

Among 34 children diagnosed to have inflammatory bowel disease (IBD) over past 8 years, 23 had Crohns disease and 11 had ulcerative colitis. Pediatric patients accounted for 7% of new cases of IBD seen annually. Median delay in diagnosis was 15 months. Nutritional impairment was significantly more common in Crohns disease.