نتایج جستجو برای: inferiority feelings
تعداد نتایج: 22583 فیلتر نتایج به سال:
INTRODUCTION There is currently little evidence for the optimal dosing strategy of four-factor prothrombin complex concentrates (PCC) in vitamin K antagonist (VKA)-related bleeds. The generally accepted dosing strategy is the use of a variable dose calculated using patient-specific characteristics as per manufacturer's instruction. However, evidence exists that the use of a fixed low dose of 10...
OBJECTIVE The aim of this prospective multicenter randomized controlled trial was to compare the efficacy of silver nitrate cauterization against that of topical steroid ointment in the treatment of neonatal umbilical granuloma. METHODS An open-label, non-inferiority randomized controlled trial was conducted from January 2013 to January 2016. The primary endpoint for the silver nitrate cauter...
Although the AIDS pandemic has catastrophic implications for all levels of South African society, it can be viewed as an opportunity to face the inevitability of human mortality with dignity rather than fear and denial and to rebuild shattered communities. This article discusses issues pertaining to counseling HIV-infected persons, the counselors themselves, and families and social groups affe...
We propose a new nonparametric method for assessing non-inferiority of an experimental therapy compared to a standard of care. The ratio E R of true median survival times is the parameter of interest. This is of considerable interest in clinical trials of generic drugs. We think of the ratio E R m m of the sample medians as a point estimate of the ratio E R . We use the Fieller-Hinkley ...
Background Treatment effect is traditionally assessed through either superiority or non-inferiority clinical trials. Investigators may find that because of safety concerns and/or wide variability across strata of the superiority margin of active controls over placebo, neither a superiority nor a non-inferiority trial design is ethical or practical in some disease populations. Prior knowledge ma...
You You ' ' ve heard a lot about NI trials already, so I ve heard a lot about NI trials already, so I ' ' ll try not to ll try not to repeat. The critical issues are, by now known to you: repeat. The critical issues are, by now known to you: 1. In most cases NI trials pose inferential problems, but 1. In most cases NI trials pose inferential problems, but you use them when you have no choice, i...
Homeopathy is a complementary and integrative medicine used in depression, The aim of this study is to investigate the non-inferiority and tolerability of individualized homeopathic medicines [Quinquagintamillesmial (Q-potencies)] in acute depression, using fluoxetine as active control. Ninety-one outpatients with moderate to severe depression were assigned to receive an individualized homeopat...
Most, if not all the current statistical literature on online randomized controlled experiments, (commonly referred to as “A/B Tests”), focuses on superiority designs. That is, the error of the first kind is formulated as incorrectly rejecting a composite null hypothesis of the treatment having no effect or having a negative effect. It is then controlled via a statistical significance threshold...
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