Although more than 3000 antibiotics have been reported from Actinomycetes/ higher fungi; biotechnological potential of yeasts and yeast-like fungi with respect to production of antimicrobial compounds has not been sufficiently investigated. We examined the antimicrobial activity of 11 strains of Aureobasidium pullulans (two new isolates and nine standard strains). All the strains of Aureobasidi...

conclusions totally, our results showed nanosilver caused an increase of at least nine-fold in inhibitory effect of fluconazole. materials and methods we studied effect of fluconazole, nanosilver, and their combination on 20 fluconazole-resistant c. albicans from two centers and one standard sample (atcc10261) by minimal inhibitory concentration (mic) method. background opportunistic fungi caus...

In 55 instances, a single proprietary (trade) name has been used to market > or = 2 distinct generic anti-infective agents. In some cases, one trade name represents 2 different drugs in the same country--or even marketed by the same manufacturer. Some unrelated drugs and poisonous substances are also manufactured under trade names assigned to anti-infectives. The use of proprietary names in the...

Fungal diseases of fish have become increasingly important, over the past 20 years. The traditional ‘‘fungi’’ are comprised members from several different taxonomic kingdoms. An increasing number other environmental fungi being reported diseased fish, further testament to opportunistic nature many fungi. Active fungal agents living in waters cause infections juvenile and adult individuals popul...

efficiency of pleurotus ostreatus and p. sajor-caju as biocontrol agents of the root knot nematode, meloidogyne javanica, was evaluated in vitro and in greenhouse experiments. population of the nematode were prepared and nematicidal effects of culture filtrates of the fungal specieson second stage juveniles of m. javanica were tested. substrates completely colonized by tested fungi as fungal in...

Introduction Heparanase is an endo-b-glucuronidase that cleaves highly potent heparan sulfate (HS) from its proteoglycan, thereby triggering the inflammatory response in [1]. Thus, new anti-infective agents that interact with heparanase may be promising tools for sepsis therapy. As a novel anti-infective agent, peptide 19-2.5 (pep2.5) belongs to the class of synthetic anti-lipopolysaccharide pe...

Program Description With antimicrobial resistance on the rise and very few new pharmaceutical agents in development, a well-managed antimicrobial stewardship program in the hospital becomes the first-line defense against the emergence of resistance and provides not only a cost-containment measure but also ensures the continued efficacy of available antimicrobials. A successful stewardship progr...

A significant number of patients with abdominal infection develop advanced stages of infection and mortality is still above 20%. Failure is multifactorial and is associated with an increase of bacterial resitance, inappropriate empirical treatment, a higher comorbidity of patients and poor source control of infection. These guidelines discuss each of these problems and propose measures to avoid...

Concise guidelines are presented that recommend the method of choice for skin antisepsis before central neuraxial blockade. The Working Party specifically considered the concentration of antiseptic agent to use and its method of application. The advice presented is based on previously published guidelines, laboratory and clinical studies, case reports, and on the known properties of antiseptic ...