Hepatitis C virus (HCV) core protein is essential for virus assembly. HCV core protein was expressed and purified. Aptamers against core protein were raised through the selective evolution of ligands by the exponential enrichment approach. Detection of HCV infection by core aptamers and the antiviral activities of aptamers were characterized. The mechanism of their anti-HCV activity was determi...

Few diseases have sprung into prominence more quickly than have the infectious hepatitides-infectious hepatitis and serum hepatitis. Both British and American troops suffered heavily during the World War years 1939-1945. During this period these diseases were assigned to the category of virus diseases, and extensive investigations were carried out in many laboratories in an attempt to isolate a...

The clinical features of an infectious erythema which affected children and young people are described. Other writers have described the same disease and have suggested a viral origin. A cytological method is described which may establish the diagnosis, and the cytological appearances might also be useful in differentiating between erythema and measles.

Introduction: Hepatitis B is a disease caused by the hepatitis B virus (HBV), which is transmitted through percutaneous (i.e., puncture through the skin) or mucosal (i.e., direct contact with mucous membranes) exposure to infectious blood or body fluids. HBV can cause chronic infection, resulting in cirrhosis of the liver, liver cancer, liver failure, and death. Persons with chronic infection a...

Hepatitis delta virus (HDV) particles are coated with the large (L), middle (M), and small (S) hepatitis B virus envelope proteins. In the present study, we constructed glycosylation-defective envelope protein mutants and evaluated their capacity to assist in the maturation of infectious HDV in vitro. We observed that the removal of N-linked carbohydrates on the S, M, and L proteins was tolerat...

Introduction / objectives Injuries from needles and sharps by health professionals, are considered extremely dangerous because they are potentially capable of transmitting microorganisms, and the human immunodeficiency virus (HIV), Hepatitis B and Hepatitis C, are the infectious agents most commonly involved. Institutions should seek to minimize risk as much as possible through measures includi...