The failure of induction of tryptophan pyrrolase (TP) in the majority of hepatomas after the administration of substrate or hormone was shown probably to be the result of a basic defect in the tumor cell itself, and not of the lowered blood flow or the lack of portal blood supply to the tumor. Two exceptions, Hepatomas H-35 and 7793, were shown to have a significant sub strate induction in the ...

An increasing number of cancer patients are using complementary and alternative medicines (CAM) in combination with their conventional chemotherapeutic treatment. Considering the narrow therapeutic window of oncolytic drugs, this CAM use increases the risk of clinically relevant herb-anticancer drug interactions. Such a relevant interaction is that of St. John's wort with the anticancer drugs i...

We analyze a system-level model for lytic repression of lambda phage in E. coli using reliability theory, showing that the repressor circuit comprises four redundant components whose failure mode is prophage induction. Our model reflects the specific biochemical mechanisms involved in regulation, including long-range cooperative binding, and its detailed predictions for prophage induction in E....

Induction therapy a. Combination treatment with cyclophosphamide plus prednisolone should be used for induction of disease remission when organ function is threatened. Both intravenous (IV) and oral cyclophosphamide show equal clinical efficacy and toxicity. (Level II evidence) b. Methotrexate is an alternative to cyclophosphamide-based induction therapy in patients with milder, early disease (...

Due to speed fluctuations of unregulated wind turbines, the terminal voltage may increase to dangerously high levels which have been reported to cause capacitor failure at wind farms. In this topic this paper examines a steady state performance analysis of stand-alone double stator induction generator self excited with two independents capacitors banks. An impedance approach based on double thr...

All-trans retinoic acid (ATRA) induced rhabdomyolysis in the induction treatment of acute promyelocytic leukemia (APL) is a very rare complication. However, rhabdomyolysis-related acute renal failure increases the risk of high morbidity and mortality. Here we describe a case of rhabdomyolysis associated with ATRA during the induction therapy in an adult with APL. Clinical implications are discu...

Use of etomidate for anesthesia induction is still debated. In the previous issue of Critical Care, Heinrich and colleagues reported that etomidate for anesthesia induction had similar outcome in comparison with other drugs, in a specific population of 3,054 patients ahead of major cardiac surgery. For the authors, the similar outcomes for mortality and length of hospital stay add to the hemody...

Induction motors can be modeled in different ways for correct operation and control, one of these is the ? - ? representation, this model has six state variables that monitored: rotor position, speed, flux, current current. Usually, only three measured directly with sensors. These sensors are subject to long periods work stress, so a failure cannot ruled out. Sensor cause problems control motor...

Adipose tissue lipolysis occurs during the development of heart failure as a consequence of chronic adrenergic stimulation. However, the impact of enhanced adipose triacylglycerol hydrolysis mediated by adipose triglyceride lipase (ATGL) on cardiac function is unclear. To investigate the role of adipose tissue lipolysis during heart failure, we generated mice with tissue-specific deletion of AT...

background: renal complication of leptospirosis is common and its clinical manifestations vary from urinary sediment changes to acute renal failure. the aim of this study was to determine the final outcome of renal involvement in leptospirosis. methods: this longitudinal prospective study included all serologically confirmed cases of leptospirosis with evidence of renal failure. all patients we...