Post-radiation syndrome is proposed to be chronic fatigue syndrome (CFS) or a chronic fatigue syndrome-like illness, initiated by exposure to ionizing radiation. This view is supported by the nitric oxide/peroxynitrite (NO/ONOO-) cycle mechanism, the putative etiologic mechanism for CFS and related illnesses. Ionizing radiation may initiate illness by increasing nitric oxide levels via increase...

Introduction Approximately 6 years ago, nitric oxide was identified as the endothelium-derived relaxing factor (EDRF), the endogenous vasodilator mimicked by nitroglycerin and nitroprusside [ 1-41. An astonishing variety of tissues synthesize nitric oxide, which has important roles in the control of systemic blood pressure, respiration, digestion, penile erection, platelet aggregation, cerebral...

Sepsis is a systemic inflammatory response syndrome caused by an infection and remains as a major challenge in health care. Many studies have reported that pioglitazone may display anti-inflammatory effects. This study was designed to evaluate the effect of subchronic treatment with pioglitazone on high-grade septic mice survival and nitrergic system involvement. Diffused sepsis was induced by ...

The NADPH-diaphorase (NADPH-d) histochemical technique is commonly used to localize the nitric oxide (NO) produced by the enzyme nitric oxide synthase (NOS) in neural tissue. The expression of inducible nitric oxide synthase (iNOS) is induced in the late stage of cerebral ischemia, and NO produced by iNOS contributes to the delay in recovery from brain neuronal damage. The present study was per...

ABSTRACT We analyzed the mechanisms underlying enhanced IgA production in cells of Peyer's patch via membrane vesicles derived from Lactobacillus sakei subsp. NBRC 15893. Depletion CD11c+ suppressed mediated by vesicles. Meanwhile, stimulation bone-marrow–derived dendritic with increased gene expression inducible nitric oxide synthase, retinaldehyde dehydrogenase 2, and several inflammatory cyt...

The aim of this study was to determine the immunoreactivity of neuronal and inducible nitric oxide synthetase, argininosuccinate synthetase, argininosuccinate lyase, glutamine synthetase in different regions of brain in rats of kainic acid mediated epilepsy. Male Sprague-Dawley rats were used in this study. The acute group animals were sacrificed after 2 hours and the chronic group animals were...