نتایج جستجو برای: inducible expression of ifn

تعداد نتایج: 21238699  

2014
Christoph Thelemann Remzi Onur Eren Manuel Coutaz Jennifer Brasseit Hanifa Bouzourene Muriel Rosa Anais Duval Christine Lavanchy Vanessa Mack Christoph Mueller Walter Reith Hans Acha-Orbea

Immune responses against intestinal microbiota contribute to the pathogenesis of inflammatory bowel diseases (IBD) and involve CD4(+) T cells, which are activated by major histocompatibility complex class II (MHCII) molecules on antigen-presenting cells (APCs). However, it is largely unexplored how inflammation-induced MHCII expression by intestinal epithelial cells (IEC) affects CD4(+) T cell-...

Journal: :Journal of immunology 2013
Tomoh Matsumiya Fei Xing Masayuki Ebina Ryo Hayakari Tadaatsu Imaizumi Hidemi Yoshida Hideaki Kikuchi Matthew K Topham Kei Satoh Diana M Stafforini

IFN-ε is a unique type I IFN whose constitutive expression in lung, brain, small intestine, and reproductive tissues is only partially understood. Our previous observation that posttranscriptional events participate in the regulation of IFN-ε mRNA expression led us to investigate whether the 5' and/or 3' untranslated regions (UTR) have regulatory functions. Surprisingly, we found that full-leng...

Journal: :Journal of virology 2014
Anshuman Das Phat X Dinh Debasis Panda Asit K Pattnaik

UNLABELLED In a genome-wide small interfering RNA (siRNA) screen, we recently identified the interferon (IFN)-inducible protein 35 (IFI35; also known as IFP35) as a factor required for vesicular stomatitis virus (VSV) infection. Studies reported here were conducted to further understand the role and requirement of IFI35 in VSV infection. Consistent with the siRNA screening data, we found that d...

Journal: :avicenna journal of medical biotechnology 0

background: infectious bursal disease virus (ibdv) causes a highly immunosuppressive disease in chickens and is a pathogen of major economic importance to the poultry industry worldwide. the vp2 protein is the major host-protective immunogen of ibdv and has been considered as a potential subunit vaccine against the disease. vp2 coding sequence was cloned in an inducible fungal vector and the pr...

2012
Wei Yang Juan Tan Ruikang Liu Xiaoxu Cui Qinglin Ma Yunqi Geng Wentao Qiao

BACKGROUND Interferon-induced 35-kDa protein (IFP35) plays important roles in antiviral defense and the progression of some skin cancer diseases. It can be induced by interferon-γ (IFN-γ) in multiple human cells. However, the mechanisms by which IFN-γ contributes to IFP35 induction remain to be elucidated. METHODS/PRINCIPAL FINDINGS We identified the transcription start sites of IFP35 by 5' r...

2014
Yoji Tsugawa Hiroki Kato Takashi Fujita Kunitada Shimotohno Makoto Hijikata

Several viruses are known to infect human liver and cause the hepatitis, but the interferon (IFN) response, a first-line defense against viral infection, of virus-infected hepatocytes is not clearly defined yet. We investigated innate immune system against RNA viral infection in immortalized human hepatocytes (HuS-E/2 cells), as the cells showed similar early innate immune responses to primary ...

Journal: :Journal of virology 2003
Yuhong Zhang Mohammad Jamaluddin Shaofei Wang Bing Tian Roberto P Garofalo Antonella Casola Allan R Brasier

Respiratory syncytial virus (RSV) is a mucosa-restricted virus that is a leading cause of epidemic respiratory tract infections in children. RSV replication is a potent activator of the epithelial-cell genomic response, influencing the expression of a spectrum of cellular pathways, including proinflammatory chemokines of the CC, CXC, and CX(3)C subclasses. Ribavirin (1-beta-D-ribofuranosyl-1,2,...

Introduction: The effects of the low dose of ionizing radiation are not thoroughly evident due to an unavoidable increase of occupational exposure and the widespread application of ionizing radiation in medical and industrial fields. The aim of this study was to investigate immune system responses following the low doses of ionizing radiation. Materia...

2017
Chiara Angiolilli Pawel A Kabala Aleksander M Grabiec Iris M Van Baarsen Bradley S Ferguson Samuel García Beatriz Malvar Fernandez Timothy A McKinsey Paul P Tak Gianluca Fossati Paolo Mascagni Dominique L Baeten Kris A Reedquist

OBJECTIVES Non-selective histone deacetylase (HDAC) inhibitors (HDACi) have demonstrated anti-inflammatory properties in both in vitro and in vivo models of rheumatoid arthritis (RA). Here, we investigated the potential contribution of specific class I and class IIb HDACs to inflammatory gene expression in RA fibroblast-like synoviocytes (FLS). METHODS RA FLS were incubated with pan-HDACi (IT...

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