In this issue of ONCOLOGY, Dr. Kuter insightfully summarizes the differential diagnosis and management of thrombocytopenia in cancer patients.[1] Chemotherapy-induced thrombocytopenia causes nearly two-thirds of cases of thrombocytopenia in the cancer setting.[2] In patients receiving chemotherapy, thrombocytopenia leads to dose reductions in 15% of treatment cycles and chemotherapy delays in 6...

Hypersensitivity to drugs may lead to the development of drug-induced platelet antibodies and consequently thrombocytopenia and bleeding, usually in the form of purpura. The association of drug and purpura was reported by Vipan(1) even before the role of platelets in haemostasis was recognised. The relationship between drug ingestion and thrombocytopenia was demonstrated by Rosenthal in 1928 wh...

We report a case of severe daptomycin-induced immune thrombocytopenia in a patient treated for methicillin-resistant Staphylococcus epidermidis and ampicillin-resistant Enterococcus faecalis bacteremia acquired in an intensive care unit. Serum antibodies bound to platelets in the presence of daptomycin on flow cytometry. There was no evidence of other causes of thrombocytopenia. The patient die...

Vancomycin-induced thrombocytopenia is a rare adverse reaction that may be overlooked because no specific diagnostic test is currently available. We herein report a patient with vancomycin-induced immune thrombocytopenia who was diagnosed by the detection of vancomycin-dependent anti-platelet antibody with flow cytometry. An IgG antibody in the patient's serum reacted with platelets only in the...

In this issue of Blood, Linkins et al report on a prospective cohort study evaluating the combination of 4Ts (magnitude of thrombocytopenia, timing of onset of thrombocytopenia, thrombosis or other clinical sequelae, and the likelihood of other causes of thrombocytopenia) score and platelet factor 4/heparin particle gel immunoassay (PF4/H-PaGIA) for diagnosis and management of heparin-induced t...

To the Editor I read with great interest the article " A case of isoniazid-induced thrombocytopenia: recovery with im-munoglobulin therapy " in volume 51, number 7, April 2012 issue of your journal (1). As the authors mentioned, this case represents a rare adverse event associated with isoni-azid therapy, namely, isoniazid-induced thrombocytopenia. It is well known that almost all anti-tubercul...