Clerodendron colebrookianum Walp., (Fam: Verbenaceae) locally known is "NEFAFU" is widely used for curing various diseases. Here some pharmacological properties of this plant were studied using rat & mice of either sex. Methanol extract (MLE) of various concentrations (50, 100, 200 mg/kg of body wt) were tested on animals. Carrageenin induced rat paw oedema model with three hours for oedema for...

background and objective : irritable bowel syndrome (ibs) is a functional gastrointestinal disorder. sleep disturb-ances are known to be common among individuals with this syndrome. this study aimed to determine the relationship between sleep quality and severity of intestinal symptoms in irritable bowel syndrome. materials and methods : this cross-sectional study was carried out among 201 subj...

There are two contrasting explanations of sleep: as a proximate, essential physiological function or as an adaptive state of inactivity and these hypotheses remain widely debated. To investigate the adaptive significance of sleep, we develop an evolutionary argument formulated as a tractable partial differential equation model. We allow demographic parameters such as birth and mortality rates t...

The human sleep EEG is studied using a dynamical system approach to the sleeping brain. The dynamics of the sleeping brain is governed by multiple time scales: ranging from the typical EEG oscillations at 1 − 30 Hz up to the ≈ 24h circadian rhythm. Starting point is the fastest time scale the sleep oscillations. They are described by modeling the EEG using adaptive linear models. The slower dyn...

INTRODUCTION The variability of arterial blood pressure (BP) is considered an important cardiovascular risk factor. OBJECTIVE To verify the possible associations between the postprandial and the sleeping blood pressure variability. METHODS This study evaluated systolic, diastolic, mean, pulse pressures and heart variability in 69 elderly patients in preprandial, postprandial and sleeping pe...

Copyright  2014 irjpbs The aim of this work is to study the hepatoprotective effect of polyherbal formulations contains some Indian medicinal plant. The three different herbal formulations obtained from different medicinal plant extracts were evaluated for hepatoprotective in rats by induced liver damage by paracetamol. Paracetamol (3g/kg, p.o) was administered a single dose to induce hepatoto...

This study was investigated to know whether pachymic acid (PA), one of the predominant triterpenoids in Poria cocos (Hoelen) has the sedative-hypnotic effects, and underlying mechanisms are mediated via γ-aminobutyric acid (GABA)-ergic systems. Oral administration of PA markedly suppressed locomotion activity in mice. This compound also prolonged sleeping time, and reduced sleep latency showing...