Background and Objective: Aging is a natural phenomenon which can cause changes in most organs and cells. Numerous mechanisms including oxidative stress and free radical generation is involved in the progression of the aging process. Pomegranate seed oil (PSO), has different therapeutic properties including anti-oxidant and anti-inflammatory effects. In this research, the effect of PSO against ...

INTRODUCTION CCN4, also termed WNT-inducible signaling pathway protein-1 (WISP-1), has important roles in inflammation and tissue injury. This study aimed to investigate the effect of CCN4 inhibition using monoclonal anti-CCN4 antibody (CCN4mAb) on the liver injury and fibrosis in a mouse model of liver fibrosis. MATERIAL AND METHODS The mouse liver fibrosis model was induced by carbon tetrac...

A major consequence of obstructive jaundice (OJ) in clinical practice is the development of severe liver injury, and at present, no effective treatments have been developed to protect against it. Preconditioning with damage-associated molecular pattern (DAMP) molecules has been demonstrated to protect multiple organs from injury, and histones have been recently identified as DAMP molecules. The...

Acetaminophen (APAP) overdose is a significant cause of drug-induced liver injury and acute failure. The diagnosis, screening, management APAP-induced (AILI) challenging because the complex mechanisms involved. Starting from current studies on AILI, this review focuses novel findings in field AILI. It highlights issues that need to be addressed. This supposed summarize recent research progress ...

Objective(s): Antrodia cinnamomea (AC) is found with anti-inflammatory and immunomodulatory biological activities. In this study, we investigated the anti-hepatitis effect of the emulsified AC extract from RO water or supercritical fluid CO2 with ethanol co-solvent extract methods of AC preparations. Materials and Methods: Five groups of eight to ten weeks male rats with a count of ten for each...

Methimazole is the most widely prescribed antithyroid medication in humans. However, hepatotoxicity is a deleterious adverse effect associated with methimazole administration. No specific protective agent has been developed against this complication yet. This study was designed to investigate the role of taurine as a hepatoprotective agent against methimazole-induced liver injury in mice. Diffe...

Objective: To study the protective effect of polyprenols on acute liver injury induced by CCl4 and D-Gal. Method: The acute liver injury model induced by 0.5% CCl4 in olive oil (10ml/kg) and D-Gal (800mg/kg, i.p.) in mice and rats respectively. 10, 40 and 160 mg/kg polyprenols was administered i.g., to study the protective effect for different doses of polyprenols, the therapeutic effect of eac...

Background: Liver surgery requires mobilization of the liver resulting in injury. Mobilization is the predominant cause of hepatocyte damage during liver surgery and jeopardizes post-operative liver function. Previously, mobilization-induced liver injury was found to be associated with inflammation. So far, anti-inflammatory drugs to potentially prevent liver inflammation following liver mobili...