Although no known meaningful health risks have been reported following the use of microbubble ultrasound echogenic contrast imaging agents (MUECIA) in the United States, premature ventricular contractions have been documented in a report from the Netherlands and anecdotally noted in clinical use. Based on this information, we designed a study to characterize electrocardiogram conduction abnorma...

To examine the origin of digitalis-induced ventricular tachycardia (VT), acetyl strophanthidin (AS) (25 mug/min) was perfused into a limited zone of myocardium in intact anesthetized dogs through a catheter placed fluoroscopically in the left anterior descending artery without ischemia. A second catheter in the great cardiac vein sampled venous effluent from this region. His and left bundle bra...

The importance of the central nervous system in the antiarrhythmic actions of diphenyhiydantoin and lidocaine was studied using arrhythmias induced by electrical stimulation of the posterior hypothalamus in cats. Hypothalamic stimulation resulted in cardiac arrhythmias mediated by the sympathetic nervous system. The arrhythmias occurred during stimulation, and recordings from cardiac sympatheti...

To evaluate the effects of hypertension on cardiac hypertrophy, on myocardial structure, and on ventricular arrhythmias, 27 3-month-old spontaneously hypertensive rats were treated with enalapril (10 mg/kg) daily for 11 months and compared with 26 untreated control rats. Systolic arterial pressure was significantly decreased in treated rats, and at the end of the experiment, it was 199 +/- 3 mm...

abstract background prolonged p-wave duration and p-wave dispersion indicate interatrial conduction disturbance and early predict arrhythmia especially atrial fibrillation. iron deposition in the atrial tissue might prolonged the atrial conduction time, and this study evaluated the p-wave prolongation and increased p-wave dispersion in these patients. materials and methods fifty patients with m...

Sudden unexpected death in epilepsy (SUDEP) accounts for 5-30% of deaths in patients with epilepsy. Past research has attempted to reveal these mechanisms, but the specific risk factors and pathophysiology have not been established. Inherited lethal cardiac arrhythmias can be erroneously diagnosed as epilepsy. A diagnosis of coexistent epilepsy cannot be completely excluded in the inherited car...

The effects of various cardiovascular drugs (prostaglandin E2 (PGE2), propranolol and nitroglycerine) and anaesthetic regimens (halothane, pethidine and pentobarbitone), upon the outcome of coronary artery ligation in acutely prepared rats were determined. Effects upon arrhythmias, blood pressure, heart rate, mortality, ECG and the size of the occluded zone were determined for each drug in the ...