The plasma concentration of indomethacin was measured after the rectal administration of water-soluble and fatty base suppositories in rats. The results were compared with the in vitro indomethacin release from suppositories determined by Paddle method using three different types of membranes: cellulose membrane, artificial sausage membrane and natural sausage membrane. The plasma concentration...

background & aim:  menopause is one of the most critical stages in a woman’s life. special attention needs to be paid to the quality of life of menopausal women. symptoms of genitourinary atrophy can affect women’s comfort and quality of life. the aim of this study was to compare two treatment methods of vitamin e suppository and conjugated estrogens vaginal cream on the quality of life of meno...

Let ? be a closed set in R n with the Lebesgue measure j?j = 0. The rst aim of the paper is to give a Fourier analytical characterization of the Hausdorr dimension of ?. Let 0 < d < n. If there exist a Borel measure with supp ? and constants c 1 > 0 and c 2 > 0 such that c 1 r d (B(x; r)) c 2 r d for all 0 < r < 1 and all x 2 ?, where B(x; r) is a ball with centre x and radius r, then ? is call...

Introduction: It is a well-known phenomenon that nonsteroidal anti-inflammatory drugs cause gastric mucosal damage. Amlodipine third generation dihydropyridine-type calcium channel blocker; it can inhibit inflammatory cytokines and enhance antioxidant defenses. N-acetylcysteine act both as precursor of reduced glutathione direct ROS scavenger. Moreover, has been purported to have properties.&#x...

BACKGROUND/AIMS We have shown that indomethacin has the potential to activate Ca2+/ calmodulin-dependent protein kinase II (CaMKII), regardless of cyclooxygenase (COX) inhibition. To understand the underlying mechanism, the present study investigated the effect of indomethacin on protein phosphatases such as protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A), and protein tyrosine phosph...

OBJECTIVE Although indomethacin produces ductus arteriosus constriction in extremely premature newborns, a recurrent symptomatic patent ductus arteriosus (PDA) frequently develops after the initial course of indomethacin. Currently, there is little information available to determine the effectiveness of a second course of indomethacin in producing permanent ductus closure. The objective of this...

The potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was the purpose of this survey. In this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of several amounts of them on the dissolution behaviour of indomethacin was investigated. It is worth mentio...