نتایج جستجو برای: indolizidine
تعداد نتایج: 138 فیلتر نتایج به سال:
Locoweed (Oxytropis sericea) is a toxic plant commonly found on rangelands in the western United States. The locoweed toxin is an indolizidine alkaloid, swainsonine that causes neurological and systemic damage. The objective of this study was to determine if feeding of locoweed to pregnant ewes during days 100–130 of gestation would affect lamb behaviour shortly after birth. Twenty yearling nul...
Citation Leonard, Effendi et al. " Opportunities in metabolic engineering to facilitate scalable alkaloid production. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract 1 2 Numerous drugs and drug precursors in the current pharmacopoeia 3 originate from plant sources. The limited yield of bioactive compounds in 4 plant...
Iminoacetonitriles participate as reactive dienophiles in intermolecular and intramolecular DielsAlder cycloadditions leading to quinolizidines, indolizidines, and piperidines. The resultant aamino nitrile cycloadducts are versatile synthetic intermediates which can be further elaborated by stereoselective alkylation, reduction, reductive cyclization, and Bruylants reactions. The first part of ...
BACKGROUND The 5,8-disubstituted indolizidines constitute the largest class of poison-frog alkaloids. Some alkaloids have been shown to act as noncompetitive blockers at nicotinic acetylcholine receptors but the proposed structures and the biological activities of most of the 5,8-disubstituted indolizidines have not been determined because of limited supplies of the natural products. We have th...
BACKGROUND The 5,8-disubstituted indolizidines are the largest class of poison-frog alkaloids found in anuran skin, and are of considerable interest because of their inhibitory effects on the neuronal nicotinic acetylcholine receptors. Many synthetic strategies for the construction of this nucleus have been reported: however, a flexible route has not been reported to date. RESULTS Synthesis o...
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