It is now recognized that between 15 and 20% of all tumors are associated with infection by direct tumorigenic agents [1]. However, the transforming mechanisms of carcinogenic infec‐ tious agents are not restricted to the expression of oncogenes and their ability to modulate the expression and function of oncogenes and anti-oncogenes in target cells. Other routes of transformation have been des...

Hundreds of tissue samples may be assembled in a tissue microarray format for simultaneous immunostaining assessment of protein expression profiling. A DNA microarray two-color laser scanner was used for automated analysis of tissue microarray indirect immunofluorescence. On sections from both a human lung adenocarcinoma and a squamous cell carcinoma tissue microarray, fluorescence intensity fo...

Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (serpin) family. It is widely expressed in human fetal and adult tissues but its expression decreases with age and in malignant tissues. The main anti-cancer activities of PEDF derive from its dual effects, either indirectly on the tumor microenvironment (indirect ant...

A theoretical link between reasoning and mathematical ability has been supported by some recent empirical evidence. We argue that some of this evidence is indirect and measure selection may have influenced this relationship. We report one study in which mathematical ability was measured using a fluency and a calculation measure (Wood-cock Johnson-III, 2001) and reasoning ability was measured us...

We analyze what functions as a YES response and a NO response for different yes/no questions. This problem is surprisingly complex: respondents do not always produce overt yes or no lexical items in response to a yes/no question. In addition, when respondents don’t include a clear yes or no word, they may mean to communicate a clear YES or NO meaning, or something else. We find that the classif...

AIM To construct the superantigen SEA (D227A) expression vector modulated by cis-acting element of AFP and express it specifically on AFP(+) hepatocellular carcinoma (HCC) cells. METHODS The enhancer and promoter of AFP gene, SEA (D227A) cDNA and linker-CD80tm were amplified by PCR. The gene segments mentioned above were cloned into the multiple cloning sites of retrovirus vector pLXSN to con...

objective: self-harm was classified to show forms like non-suicidal self injury and indirect risky behaviors and drug abuse. the aims of this study were to compare suicidal tendencies indexes and difficulty in emotion regulation skills in mixed groups of adolescents with direct and indirect forms of self-harm. methods: in a casual-comparative design from population of delinquent adolescents det...