Histiocytoses are clonal disorders diseases derived from the monocyte-macrophage lineage. The Erdheim–Chester Disease (ECD) and Langerhans Cell Histiocytosis (LCH) may occur in association with overlapping clinical, histopathological molecular features, harboring somatic MAP2K1 mutations more than 50% of patients. BRAF MEK inhibitors have shown to be efficacious ECD LCH, including responses pat...

Malignant histiocytosis (histiocytic medullary reticulosis) in a 45-year-old white man is described. Unusual features were presentation as a surgical emergency with signs of obstruction and peritonitis due to an ileal tumour and extensive spindle cell differentiation. Problems in the differential diagnosis of malignant histiocytosis are briefly discussed.

Pulmonary Langerhans cell histiocytosis is a rare interstitial lung disease. It's morbidity is estimated at 4-5 person per million. The multiformity--from benignity to severe--brings difficulties during the process of diagnosis. The authors describe a case of 48-year-old woman with a benign pulmonary lung histiocytosis. It is underlined the diagnostic quality of high resolution tomography and b...

Monoclonal antibody against histiocytosis X cells (HXCs) was established. The antigen was the cell membrane of HXCs from the submandibular lesion of a 63-year-old man who had been diagnosed as an adult type of histiocytosis X (HX) and whose HXCs had numerous Birbeck granules (BGs). The obtained monoclonal antibody, named MI1, reacted with the antigenic cell membrane of HXC. Immunoblotting showe...

BACKGROUND Pulmonary Langerhans'-cell histiocytosis is an uncommon interstitial lung disease in adults. It has an unpredictable course and may be associated with an increased susceptibility to the development of malignant neoplasms. METHODS We reviewed the records of 102 adults with histopathologically confirmed pulmonary Langerhans'-cell histiocytosis to ascertain their vital status and whet...