Background: Ferroptosis is defined as an iron-dependent non-apoptotic form of programmed cell death. Dihydroorotate dehydrogenase (DHODH) a newly discovered anti-ferroptosis molecule independent from the well-known GPX4 and AIFM2. However, expression pattern especially functional roles DHODH during cancer death are generally unknown.

Aldo-keto reductases comprise of AKR1C1-AKR1C4, four enzymes that catalyze NADPH dependent reductions and have been implicated in biosynthesis, intermediary metabolism, and detoxification. Recent studies have provided evidences of strong correlation between the expression levels of these family members and the malignant transformation as well as the resistance to cancer therapy. Mechanistically...

NURSING MANAGEMENT June 2016 | Volume 23 | Number 3 31 and potential conflicts of interest between meeting independent practice areas and HEIs’ expectations (Bower 2002), as well as the challenges of working across organisations with different structures and role priorities (Redwood et al 2002). There is a lack of research into the effectiveness of these roles in bridging the theory-practice ga...

When studying software ecosystems, i.e., software-related organizations that collaboratively provide a market, it is difficult to identify the typical roles in that software ecosystem (SECO), and whether certain organizations belong to the ecosystem or not. The main aim of this research is to perform an independent literature review in order to create a classification of the typical roles named...

In the context of implementing privileges Yogyakarta, Governor Regulation 93 2020 concerning Cultural-Independent Villages is stipulated in village development. The concept a cultural-independent described as with characteristics independence/freedom, sovereignty, integrity, and innovation. complete independent model or political language an autonomous village. Cultural-independent villages are...

Roles can be assigned to occurrences of variables in programs according to a small number of patterns of use that are both languageand algorithm-independent. The concept of roles of variables is almost certainly part of the tacit knowledge of expert programmers, and we believe that explicitly teaching roles of variables to novice students can be an excellent pedagogical tool for clarifying the ...

In this paper we initialize the study of independent domination in directed graphs. We show that an independent dominating set of an orientation of a graph is also an independent dominating set of the underlying graph, but that the converse is not true in general. We then prove existence and uniqueness theorems for several classes of digraphs including orientations of complete graphs, paths, tr...