a controlled release matrix formulation for mesalamine was designed and developed to achieve a 24 h release profile. using compritol 888 ato (glyceryl behenate) as an inert matrix-forming agent to control the release of mesalamine, formulation granules containing the solid dispersions were investigated. pectin, a polysaccharide, was used as bacterial dependent polymer for colon targeting. the m...

We investigate the level density σ(x) and the level-spacing distribution p(s) of random matrices M = AF ≠ M{†}, where F is a (diagonal) inner product and A is a random, real, symmetric or complex, Hermitian matrix with independent entries drawn from a probability distribution q(x) with zero mean and finite higher moments. Although not Hermitian, the matrix M is self-adjoint with respect to F an...

We present Object Focused Q-learning (OF-Q), a novel reinforcement learning algorithm that can offer exponential speed-ups over classic Q-learning on domains composed of independent objects. An OF-Q agent treats the state space as a collection of objects organized into different object classes. Our key contribution is a control policy that uses non-optimal Q-functions to estimate the risk of ig...

Extremal BPS-saturated black holes in N = 2, d = 4 supergravity can carry electric and magnetic charges (q (m), q (e) Λ ). It is shown that in smooth cases the moduli fields at the horizon take a fixed ”rational” value X(q(m), q ) which is determined by the charges and is independent of the asymptotic values of the moduli fields. A universal formula for the Bekenstein-Hawking entropy is derived...

Using data from ground-based vertical sounding of the ionosphere (VS) at station Moscow and five Japanese stations for period 1969 to 2015, we have examined long-term response E layer solar X-ray flares. The analysis relies on previously developed method estimating ratio between rates ionization by X-rays qx ultraviolet radiation qu during We confirmed existence a (at least covering 45-year obs...

ABSTRACT. Given a basis for a polynomial ring, the coefficients in the expansion of a product of some of its elements in terms of this basis are called linearization coefficients. These coefficients have combinatorial significance for many classical families of orthogonal polynomials. Starting with a stochastic process and using the stochastic measures machinery introduced by Rota and Wallstrom...

In this article we review the standard versions of the Central and of the Lévy-Gnedenko Limit Theorems, and illustrate their application to the convolution of independent random variables associated with the distribution Gq (X) ≡ Aq [ 1 +(q−1)Bq (X − μ̄q) ] 1 1−q (Aq > 0; Bq > 0; q < 3), known as q-Gaussian. This distribution emerges upon extremisation of the nonadditive entropy Sq ≡ k (1− ∫ [p(...

background : the one-third middle cerebral artery (1/3 mca) method and alberta stroke program early computed tomography score (aspects) were used to detect significant early ischemic changes on brain computed tomography (ct) of patients with acute stroke. we designed the persian early ct score (pects) and compared it with the above systems.   methods: the tomograms were chosen from the stroke d...