Overexpression of trefoil factor 2 (TFF2) is associated with increased cell migration, resistance to apoptosis, and possibly increased gastric cancer invasion. Dysregulation of p53 is frequently observed in preneoplastic conditions of the stomach. Here, we investigated the effect of p53 on the expression and function of TFF2 in gastric cancer cell lines. Gene expression was determined by revers...

Bisphenol-A (BPA) has been considered as an endocrine disrupting chemical (EDC) because it can exert estrogenic properties. For bisphenol-S (BPS) and bisphenol-F (BPF) that are BPA analogs and substitutes, their risk to estrogen-dependent cancer has been reported rarely compared with the numerous cases of BPA. In this study, we examined whether BPA, BPS, and BPF can lead to the proliferation, m...

MicroRNA (miR)-103a-3p has been shown to be involved in the development and progression of several types cancer. However, role miR-103a-3p thyroid cancer remains unclear. This study investigated effects on biological characteristics cells related mechanisms. In present study, we found that expression was increased tissues compared non-cancerous tissues. Additionally, cell lines (TPC-1, SW579, B...

BACKGROUND Simvastatin is widely used to lower cholesterol levels in patients with cardiovascular diseases, although accumulating evidence suggests that statins, such as simvastatin, also exert numerous anti-tumoral effects. AIM The aim of this study was to examine the effect of simvastatin on colon cancer cell migration. METHODS Migration assays were performed to evaluate CCL17-induced col...

INTRODUCTION Niacin reduces vascular oxidative stress and down regulates inducible nitric oxide synthase, an enzyme mediating proatherosclerotic effects in part by increasing oxidative stress. Here, we evaluate whether Niacin reverses the redox sensitive migratory arrest of macrophages in response to oxidised(ox) LDL uptake. MATERIAL AND METHODS Migration of RAW264.7 cells, a murine macrophag...

Abstract Annexin A5 (ANXA5) is a member of the calcium dependent phospholipid binding protein family and participates in regulation variety physiological pathological processes. However, whether how ANXA5 affects growth progression glioma remains unclear.We analyzed expression multiple public databases, verified 50 clinical samples with Western blotting to study correlation between prognosis, s...

Few studies have focused on ?-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) in tumor progression. We investigated the expression and importance of GABARAP breast cancer. analyzed its relationship with clinicopathological features prognosis (TCGA). To explain role potential mechanism regulating development, we performed acquisition loss function experiments using cell li...

The TRAPPIST-1 system is an iconic planetary in various aspects (e.g., habitability, resonant relation, and multiplicity) hence has attracted considerable attention. mass distribution of the planets characterized by two features: inner are large, masses four outer orbit increase with orbital distance. origin these features cannot be explained previous formation models. We investigate whether ca...

introduction : tardive dyskinesia is one of the major side effects of long-term neuroleptic treatment. increased reactive oxygen species and oxidative stress has been proposed as possible etiopathologic mechanisms. ginkgo biloba extract (egb) is a natural antioxidant. we investigated the effects of ginkgo biloba extract on neuroleptic-induced orofacial dyskinesia in rats, a potential animal mod...

Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in dr...