The binding stoichiometry of a host-guest complex can be effectively controlled by the redox chemistry of the guest: a 1:1 inclusion complex of methylviologen dication (MV2+) in cucurbit[8]uril (CB[8]) converts completely and reversibly to a 2:1 inclusion complex of cation radical (MV+.) in CB[8] upon the reduction of the guest.

This study was undertaken to develop tablets of diazepam-hydroxypropyl-β-cyclodextrin inclusion complex that disintegrate within 3 minutes and release 85% of drug within 30 minutes to provide rapid action of the drug through oro-mucosal route. Formation of inclusion complex was verified using X-ray diffraction and differential scanning calorimetric studies. Enhanced of aqueous solubility, as ev...

Silymarin is a hepatoprotective agent, having poor water solubility and oral absorption of about 23 - 47%, leading to low bioavailability of the drug. The aim of the present study is to improve the solubility and dissolution rate and in turn the hepatoprotective activity of the drug, by formulating its inclusion complex with beta (β)-cyclodextrin, using different methods. The phase solubility a...

Cyclodextrins (CDs) are a family of cyclic oligosaccharides which are composed of α (1,4) -linked glucopyranose subunits. Thebest-characterized forms are α, β and γ CD which are consisted of six, seven and eight D-glucose units, respectively. Cyclodextrins are produced from starch by enzymatic degradation. These macrocyclic carbohydrates with polar internal cavities can form complexes with and ...

background: the over-expression of recombinant proteins in large amount is important for production of therapeutic proteins and structural study. there are several systems for expression of recombinant proteins. one of the most relevant expression systems is escherichia coli (e. coli). although this organism has many advantages, most of recombinant proteins expressed in e. coli hosts form inclu...

abstract background and aims: one of the complications of breast cancer treatment is ipsilateral upper extremity lymphedema. secondary lymphedema is a chronic condition that leads to loss of function and disorder of quality of life. the aim of this study was to evaluate the effects of complex decongestive physical therapy (cdp) on pain severity and quality of life in patients with secondary upp...

a brief account of the representative and workable industrial minerals namely magnesite, talc and barite in lesser himalaya, is presented here emphasizing their genesis. deposits of magnesite and talc are found associated with neoproterozoic, plateform type, shelf-slope limestone-dolomite host rocks from inner lesser himalayan sequences. field, textural, geochemical signatures and fluid inclusi...

samples of formalin fixed gastrointestinal organs of three month ostrich chicks were submitted to the department of pathology, razi vaccine and serum research institute. histologically hepatitis and pancreatitis with large eosinophilic intra nuclear inclusion bodies were prominent in hepatic and pancreatic cells. these inclusions were suspected as adenovirus inclusion body hepatitis (ibh) in va...

background: the refolding of proteins from inclusion bodies is affected by several factors, including solubilization of inclusion bodies by denaturants, removal of the denaturant, and assistance of refolding by small molecule additives. objectives: the purpose of this study was optimization of recombinant human interferon-b purification in order to achieve higher efficiency, yield, and a produc...

The interaction between zaleplon (ZAL) and different cyclodextrins in aqueous solutions was investigated by spectrofluorimetric and phase solubility studies. Stability constants determined by both methods showed that among natural cyclodextrins, β-cyclodextrin (βCD) formed the most stabile complex but its solubilizing efficiency was limited. Among βCD derivatives, the complex stability and solu...