Asymmetric distribution of the hormone auxin organizes plant cell fate and drives specification of new organs. Such asymmetries are regulated by polarized auxin transporters called PINs. But what controls PIN polarity? A new study shows that another hormone, cytokinin, degrades PINs on specific membranes to direct auxin flux.

BACKGROUND Protein interaction networks (PINs) specific within a particular context contain crucial information regarding many cellular biological processes. For example, PINs may include information on the type and directionality of interaction (e.g. phosphorylation), location of interaction (i.e. tissues, cells), and related diseases. Currently, very few tools are capable of deriving context-...

BACKGROUND Pin tract infection is one of the most common complications of external fixation. We developed techniques to coat titanium implant surfaces with iodine. This study clinically evaluated the infection-preventive effects and biological safety of iodine-coated external fixation pins. PATIENTS AND METHODS Iodine-supported pins were placed in 39 limbs of 38 patients. The mean age of the ...

OBJECTIVE To compare the accuracy of radiography and computed tomography (CT) in predicting implant position in relation to the vertebral canal in the cervical and thoracolumbar vertebral column. STUDY DESIGN In vitro imaging and anatomic study. ANIMALS Medium-sized canine cadaver vertebral columns (n=12). METHODS Steinmann pins were inserted into cervical and thoracolumbar vertebrae base...

To study the effects of acupuncture analgesia on the hippocampus, we observed the effects of electroacupuncture (EA) and mitogen-activated protein kinase (MEK) inhibitor on pain-excited neurons (PENs) and pain-inhibited neurons (PINs) in the hippocampal area CA1 of sham or chronic constrictive injury (CCI) rats. The animals were randomly divided into a control, a CCI, and a U0126 (MEK1/2 inhibi...

The use of external fixation for intra-articular calcaneal fractures is increasing in popularity. Studies have shown fine wire and monoaxial external fixation to be a viable surgical alternative to more invasive methods of open reduction and internal fixation of the calcaneus. However, there is an absence of literature that quantifies the risk of pin insertion for monoaxial fixation. This study...

Cell fate diversity is generated in part by the unequal segregation of cell-fate determinants during asymmetric cell division. In the Drosophila bristle lineage, the sensory organ precursor (pI) cell is polarized along the anteroposterior (AP) axis by Frizzled (Fz) receptor signaling. We show here that Fz localizes at the posterior apical cortex of the pI cell prior to mitosis, whereas Strabism...

BACKGROUND Pin site infection is the most common and significant complication of external fixation. In this work, the efficacy of pins coated with titanium dioxide (TiO(2)) for inhibition of infection was compared with that of stainless steel control pins in an in vivo study. METHODS Pins contaminated with an identifiable Staphylococcus aureus strain were inserted into femoral bone in a rat m...

We provide the first published estimates of the difficulty of guessing a human-chosen 4-digit PIN. We begin with two large sets of 4-digit sequences chosen outside banking for online passwords and smartphone unlock-codes. We use a regression model to identify a small number of dominant factors influencing user choice. Using this model and a survey of over 1,100 banking customers, we estimate th...

This paper presents geometric algorithms for developing a re-configurable tooling system for fabrication of freeform objects. The proposed method involves a mold block, with n faces, in which the mold cavity is formed by moving a set of discrete pins on each face of the block. The part surfaces are approximated in the mold cavity using the pins from the suitable mold block faces. The geometric ...