BACKGROUND An important challenge with the application of next-generation sequencing technology is the possibility of uncovering incidental genomic findings. A paucity of evidence on personal utility for incidental findings has hindered clinical guidelines. Our objective was to estimate personal utility for complex information derived from incidental genomic findings. METHODS We used a discre...

The levels of the neuropeptides Met- and Leu-enkephalin (MET-ENK, LEU-ENK), substance P and neurotensin were measured by a combined high performance liquid chromatography/radioimmunoassay (HPLC/RIA) method in postmortem samples of basal ganglia from Parkinson's disease patients, incidental Lewy body disease patients (pre-symptomatic Parkinson's disease) and matched controls. Dopamine (DA) level...

Social cognition research suggests that incidental, environmental stimuli (e.g., business suits) can nonconsciously influence the degree to which behavioral dispositions (e.g., competitiveness) are expressed. Similarly, cognitive research suggests that incidental action-related objects (e.g., hammers) can prime action plans that then affect the speed with which a concurrent, intended action (e....

Fluorescence staining is the prevailing image acquisition technique in cell biology research. A problem of this method is the incidental fluorescence, that is the total fluorescence collected by a camera pixel originating from all sources in the sample except for the targeted point. As a result, typical images exhibit blurry regions at the periphery of fluorescence stained cell structures. Gene...

This paper considers model selection problem in the presence of incidental parameters. The main interest is in selecting the structure of the model in the common parameters after concentrating out the incidental parameters. Using KLIC based on the pro…le likelihood, a new model selection information criterion is developed, which impose heavier penalties than those of the standard information cr...

The use of brain imaging technology as a common tool of research has spawned concern and debate over how investigators should respond to incidental findings discovered in the course of research. In this article, we argue that investigators have an obligation to respond to incidental findings in view of their entering into a professional relationship with research participants in which they are ...

The study was designed to determine if spatial location of movement was automatically encoded in memory by children with intellectual disabilities (ID) and typically developing (TD) children. Each participant performed motor exercises at each of four selected locations on a 20X20 m field. The condition variable consisted of intentional position-intentional exercise, incidental position-intentio...

STUDY DESIGN A retrospective, long-term follow-up study. OBJECTIVES To find out whether incidental durotomy in lumbar disc surgery is associated with long-term sequelae. SUMMARY OF BACKGROUND DATA Incidental durotomy is a frequent complication during spinal surgery. Little is known about the clinical long-term outcome. METHODS The study population comprised 1,280 patients who underwent st...

Although functional neuroimaging studies have supported the distinction between explicit and implicit forms of memory, few have matched explicit and implicit tests closely, and most of these tested perceptual rather than conceptual implicit memory. We compared event-related fMRI responses during an intentional test, in which a group of participants used a cue word to recall its associate from a...

The incidental thyroid nodule (ITN) is one of the most common incidental findings on imaging studies that include the neck. An ITN is defined as a nodule not previously detected or suspected clinically, but identified by an imaging study. The workup of ITNs has led to increased costs from additional procedures, and in some cases, to increased risk to the patient because physicians are naturally...