In this study, methoxylated flavonoids and volatile constitutions of Agrostis gigantea Roth (Poaceae) were investigated for the first time. The flavonoids were identified by spectroscopic methods (1H-NMR, 13C-NMR, COSY, NOSEY, TCOSY, and HMBC). The volatile constitutions of aerial parts and seeds were analyzed by gas chromatography–mass spectrometry (GC-MS). Two methoxylated flavonoids, luteoli...

Background: Essential oils are found to have multiple active components which can show in vitro cytotoxic action against various cancerous cell lines. This study reports the in vitro cytotoxic effects of the essential oil from Artemisia absinthium L. (Asteraceae) growing wild in Iran. Methods: Water-distilled essential oil of A. absinthium collected from Ardabil, north-western Iran, was examin...

Measuring the potentially adverse effects of materials on human body is vital and essential for their use, including medical applications. One properties that need to be known cytotoxic effect avoid local systemic effects. It very important scientists professionals are aware body. This study also summarizes data morphology, chemical composition, ethylene-vinyl acetate (EVA) orthopaedic cytotoxi...

It is likely that many different in vitro cytotoxicity methods could be used to help select the in vivo starting dose for an acute lethality assay. Two decades of experience indicate that in vitro basal cytotoxicity data determined in various primary cells, as well as in various permanent nondifferentiated finite or transformed cell lines, generally show comparable cytotoxic concentrations of t...

background: rosa damascena is a traditional medicinal plant used in asia to treat several ailments. this study reports in vitro and in vivo antioxidative properties and toxicity of methanolic and aqueous extracts of white rose, an indigenous variety of rosa damascena from iran. methods: the antimicrobial activities, total phenolics, antioxidative properties and the blood sera ferric-reducing an...

background: nanoparticles have become one of the leading technologies over the past two years. the extensive use of nanoparticles has raised great concern about their occupational fate and biological effects. with an increase in the production and use of nanomaterial, it is more likely to get exposed to them occupationally and environmentally. objective: to assess the toxicity of silver nanopar...

The expression of immunoglobulins by cancer cells have been known for two decades. However, the mechanisms of action behind these cancerous immunoglobulins (cIgG) are not well understood and may be different from immunoglobulins secreted by normal B lymphocytes. Therefore, the structural and functional roles of cIgG have been actively investigated to resolve this mystery. A monoclonal antibody,...

Background: In the last few years, a marked decrease in male fertility has been reported. Environmental factors were recently suspected for this problem. The misuse of medicines especially antibiotics are among environmental factors that can affect reproductive system. Ciprofloxacin is a synthetic antibacterial agent belonging to the family of fluoroquinolones with a very broad spectrum effect ...

A new group of 4-(Imidazolylmethyl) quinoline derivatives possessing a methylsulfonyl COX-2 pharmacophore at the para position of the C-2 phenyl ring were designed and synthesized as selective COX-2 inhibitors and in-vitro anti breast cancer agents. In-vitro COX-1 and COX-2 inhibition studies showed that all the compounds were potent and selective inhibitors of the COX-2 isozyme with IC50 value...

The major challenge to treat Parkinson’s disease (PD) is penetration of target molecule into the brain to improve the efficacy of drugs. To achieve better brain penetration and targeted delivery, 1,9-Pyrazoloanthrone (1,9-P) loaded liposomes were developed by solvent injection technique using ultrasonication and evaluated for particle size, morphology, entrapment efficiency, FT-IR, and in-vitro...