BACKGROUND AND PURPOSE Results regarding protective effects of dipeptidyl peptidase 4 (DPP4) inhibitors in renal ischaemia-reperfusion injury (IRI) are conflicting. Here we have compared structurally unrelated DPP4 inhibitors in a model of renal IRI. EXPERIMENTAL APPROACH IRI was induced in uninephrectomized male rats by renal artery clamping for 30 min. The sham group was uninephrectomized b...

While the ASEAN Political-Security Community (APSC) Blueprint 2025 envisages a centrality of regional architecture in responding to security challenges region, divided positions among member states – mostly visible South China Sea dispute have deepened pessimism on fate APSC. Notwithstanding persisting intra-ASEAN disunity, organization has been projecting goal global political arena. The highl...

Fucoidan has been reported to exhibit various beneficial activities ranging from to antivirus and anticancer properties. However, little information is available about the effects of fucoidan on cerebral ischemia-reperfusion injury (IRI). Our study aimed to explore the effects of fucoidan on cerebral IRI, as well as the underlying mechanisms. Sprague-Dawley (SD) rats were randomly subjected to ...

As the Asian country with the most aged population, Japan, has been modifying its social welfare system. In 2000, the Japanese social care vision turned towards meeting the elderly's care needs in their own homes with proper formal care services. This study aims to understand the quantitative properties of the macro supply and demand structure for facilities for the elderly who require support ...

india, the second most populous country in the world enjoying 6% economic growth during the last years of the twentieth century, is considered as a newly emerged power, and is predicted to be the fourth economic power by 2025. development of military might, outstanding software power particularly in space industry and entering nuclear technology arena provide a special position for india in the...

Ischemia-reperfusion injury (IRI) is induced as a result of reentry of the blood and oxygen to ischemic tissue. Antioxidant and some other drugs have protective effect on IRI. In many surgeries and clinical conditions IRI is counteract inevitable. Some anesthetic agents may have a protective role in this procedure. It is known that inhalational anesthetics possess protective effects against IRI...

The distribution of salivary immunoreactive insulin (S-IRI) and its relation to plasma insulin (P-IRI) and other clinical and metabolic variables were investigated in 93 nondiabetic subjects (60 males, 33 females, ages 11-70 y). S-IRI was measured by RIA, with monoiodinated insulin as labeled antigen and with standards consisting of serial dilutions in saliva of known amounts of native insulin....

Background: The impact of hepatic steatosis on bioenergetics following hepatic ischemia-reperfusion injury (IRI) remains controversial and is associated with variable reports on its outcome. Large numbers of studies have been published examining the relationship between hepatic steatosis and cellular bioenergetics following hepatic IRI. This systematic review evaluates these studies. Methods: A...

Deterioration models are important and essential part of any Pavement Management System (PMS). These models are used to predict future pavement situation based on existence condition, parameters causing deterioration and implications of various maintenance and rehabilitation policies on pavement. The majority of these models are based on roughness which is one of the most important indices in p...