Hydroxychloroquine (HCQ) is a commonly used medication for its immunosuppressive and dermatologic effects. It has known ocular side effects, which include retinopathy, corneal deposits, choroidal thinning. Herein, we report the first case of HCQ-induced hyperpigmentation sclera. A 75-year-old female presented after 10 months gradual progression painless blue-gray discoloration bilateral sclera,...

Trichophyton rubrum is a common agent found in superficial mycoses, which present ample non-inflammatory lesions, with chronic evolution, especially in immunocompromised patients. The hypercortisolism in Cushing's syndrome increases the risk of infections as a result of the immunosuppressive effect of glucocorticoids. The reported cases here refer to two different types of dermatophytosis cause...

Tacrolimus is an immunosuppressive agent that can show a wide variety of neurologic side effects, including leukoencephalopathy. Although the prognosis is good-after cessation or dose reduction, complete recovery usually occurs-the differentiation with treatable diseases such as progressive multifocal encephalopathy can be difficult, making a stereotactic biopsy of the white matter lesion somet...

We report a patient with a systemic vasculitis and heart involvement with complete atrio-ventricular block. After pacemaker implantation, the stimulation threshold significantly increased resulting in exit block. Two adjunctive ventricular leads were implanted with temporary threshold improvement. Oral glucocorticoids decreased the stimulation threshold with a transient, dose-dependent efficacy...

Administration of cyclosporine (CS) as an immunosuppressive agent in clinical tr a:s plan tation is associated with multiple side effects including nephrotoxicity ald hypertension. These two effect~ could be related in that the renal changes may be secondary to alterations in organ blood flow. The present studies investigate the ability of CS to augment contractile responsiveness in blood vesse...

Lymphoid interstitial pneumonitis (LIP) is a rare clinicopathological entity that may be associated with common variable immune deficiency (CVID) and may lead to respiratory failure and death. Some patients may respond to prolonged corticosteroid treatment. We hypothesised that, in view of the predominant T cell nature of LIP, cyclosporin A would be a more appropriate choice of immunosuppressiv...

FK 506, a powerful. new immunosuppressive agent, is currently undergoing clinical trials in transplant patients. Like cyclosporine (CyA). FK 506 suppresses interleukin-2 production and receptor expression on T cells. 1.2 Additionally, both FK 506 and CyA are highly lipophilic. 3 CyA is mainly transported by lipoproteins in plasma.4 The objective of the present study is to characterize the distr...

The immunosuppressive properties of Glucuronoxylomannnan (GXM), a purified capsular polysaccharide of the opportunistic fungus Cryptococcus neoformans, have been extensively elucidated. GXM can inhibit the function of cells belonging to both the innate and adaptive immune systems, leading to inhibition of proinflammatory responses as well as of autoimmune inflammation.This review focuses on the...

Everolimus (Certican,® Novartis Pharma AG, Basel, Switzerland), a macrolide antibiotic derived by chemical modification of a natural product, sirolimus (Rapamune,® Wyeth-Ayerst, Princeton, NY, USA), is a potent immunosuppressive agent that prevents the rejection of solid organ grafts [1, 2]. Therapeutic drug monitoring (TDM) plays a key role in maintaining blood everolimus concentrations within...

Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function. It can develop as the result of congenital marrow disease and chemical exposure; however, most cases are idiopathic.1 Treatment with immunosuppressive therapy (IST) for patients who do not have an human leukocyte antigen (HLA)-compatible donor relies on the evidence that a deregulated immune system dri...