The activity of the immune system in reproductive tract has been proven to be crucial response uterine diseases, normal functions, and tolerance allogeneic fetus during pregnancy. objectives current study were (1) evaluate vaginal cytokine concentrations postpartum cows undergoing estrus synchronization followed by timed artificial insemination (TAI) (2) correlate bacterial communities with con...

The therapeutic potential of monoclonal antibodies (mAbs) makes them an ideal tool in both clinical and research applications due to their ability to recognize and bind specific epitopes with high affinity and selectivity. While mAbs offer significant therapeutic potential, their utility is overshadowed by the cost associated with their production, which often relies on the ability to identify ...

A method has been developed for routine high yield separation of canalicular (cLPM) from basolateral (blLPM) liver plasma membrane vesicles of rat liver. Using a combination of rate zonal floatation (TZ-28 zonal rotor, Sorvall) and high speed centrifugation through discontinuous sucrose gradients, 9-16 mg of cLPM and 15-28 mg of blLPM protein can be isolated in 1 d. cLPM are free of the basolat...

BACKGROUND AND PURPOSE Neuromyelitis optica (NMO) is an idiopathic mostly relapsing inflammatory disease with attacks on the optic nerves and spinal cord. Whether NMO is a separate disease or a subtype of classic multiple sclerosis (MS) is unclear. Clinically, CSF and MR imaging parameters and histopathologic data suggest that the normal-appearing white matter (NAWM) may be affected in MS but n...

Although mouse models of inflammatory skin diseases such as psoriasis and atopic dermatitis fail to completely phenocopy disease in humans, they provide invaluable tools to examine the molecular and cellular mechanisms responsible for the epidermal hyperplasia, inflammation, and excess angiogenesis observed in human disease. We have previously characterized a tyrosine kinase with immunoglobin-l...

There is evidence from the study of twins (Lenz, 1963; Carter, 1969) of a genetic predisposition to certain diseases, in particular pulmonary tuberculosis. But there are apparently no published reports of an association of pulmonary tuberculosis and ABO-Rh blood groups, haemoglobin, and immunoglobin types. Saha and Banerjee (1968) could not establish an association between ABO-Rh blood groups a...

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