Immediate hypersensitivity (IHS) reactions to macrolides and to macrolide-derived antibiotics like pristinamycin are uncommon. In this context, there is little data available to appreciate the true value of biological tools regarding the diagnosis of immediate allergy to pristinamycin. Here we assess the clinical usefulness of the basophil activation test (BAT) to differentiate allergic from no...

the study aimed to assess the prevalence and associated risk factors of immediate-type hypersensitivity reactions (hrs) to drugs in workers. the data consisted of 1152 questionnaires obtained from adult men that consisted of questions on hrs induced by drugs. the prevalence of self-reported drug hrs was 3.6% for all reactions. hrs were most common to beta-lactam antibiotics (51.2%) followed by ...

Hypersensitivity to rubber is usually reported as contact dermatitis due to substances used in its processing; however, recent reports in patients attribute IgE mediated reactions specifically to latex and not to chemical additives. These patients were first seen with contact urticaria, but tissue contact with both medical and non-medical latex rubber may also precipitate anaphylactic reactions...

Immediate-type drug hypersensitivity is an increasingly significant clinical issue; however, the diagnosis is frequently hindered due to lack of safe and precise diagnostic tests. Flow cytometry-assisted basophil activation test is a safe in vitro diagnostic tool for assessing basophil activation upon allergen stimulation. In this review, we have summarized current literature on the diagnostic ...

Background Cephalosporin is one of the most commonly used beta-lactam antibiotics globally, and also a major offending agent of drug hypersensitivity along with penicillin. Cephalosporin skin test has been widely used in most hospitals in Korea. However, the validity of this test for prediction of immediate hypersensitivity has still not been well studied. Therefore, we conducted this study to ...

Local anesthetics are widely used in clinical practice, and adverse effects are not uncommon. Delayed hypersensitivity reactions are among the most common effects, but immediate-type reactions may also occur. Patch testing should be considered in patients with hypersensitivity reactions. We present a case of allergic contact dermatitis to benzocaine that was detected incidentally by patch testi...

The immune response against helminths and allergens is generally characterized by high levels of IgE and increased numbers of Th2 cells, eosinophils, and mast cells, yet the clinical outcome with respect to immediate hypersensitivity and inflammation is clearly not the same. High levels of IgE are seen to allergens during helminth infections; however, these IgE responses do not translate into a...

The present histological studies have demonstrated that histamine causes dose-dependent eosinophil infiltration into the conjunctiva. A highly directional movement toward the conjunctival epithelium was observed, and the presence of large numbers of degranulating eosinophils appeared to result in epithelial cell damage and goblet cell discharge. Blockade of H2-receptors by systemic cimetidine p...

BACKGROUND Iodinated contrast media cause both immediate and nonimmediate hypersensitivity reactions. The aim of this prospective study was to determine the specificity and sensitivity of skin tests in patients who have experienced such reactions. METHODS Skin prick, intradermal and patch tests with a series of contrast media were conducted in 220 patients with either immediate or nonimmediat...

Although severe reactions to immunoglobulin preparations have been frequently reported, IgE antibodies against IgA are usually not investigated; and occur predominantly in previously sensitized patients. The purpose is to report anaphylaxis to IGIV during initial infusion in a patient with common variable immunodeficiency with absent IgA without prior sensitization and in the absence of detecta...