393 Abstract: In this study we have showed that zinc ion has an inhibitory activity on imipenem and meropenem suspectibility of Pseudomonas aeruginosa. When zinc ion concentration of Mueller-Hinthon agar (MHA) media was gradually increased the zone diameters of imipenem and meropenem gradually decreased. So we concluded that zinc concentration in the media might effect imipenem and meropenem su...

We investigated the binding affinities of SM-7338 for penicillin-binding proteins (PBPs) and the morphological changes induced by it compared with those of imipenem. Both SM-7338 and imipenem had the highest binding affinities for PBP-2 of Escherichia coli, which were in good agreement with the primary morphological response of spherical cell formation. SM-7338 also showed high affinities for P...

BACKGROUND Recent analyses of hospital outbreaks have documented the spread of resistance to imipenem, which is currently a major problem among gram positive and gram-negative bacteria. The aim of this study was to describe the rate of gram-positive and gram-negative isolates resistance to imipenem as an antibiotic. METHODS Recorded files of 242 hospitalized patients with at least one sample ...

32 Background 33 There are currently no defined optimal therapies available for multidrug-resistant 34 (MDR) Acinetobacter baumannii infections. We evaluated the efficacy of rifampin, 35 imipenem, sulbactam, colistin, and their combinations against MDR A. baumannii in 36 experimental pneumonia and meningitis models. 37 Methods 38 The bactericidal in vitro activity of rifampin, imipenem, sulbact...

Although imipenem is not a first-line drug for treating enterococcal infection, it could well become a useful drug for treating mixed infections that include enterococci. However, there is no NCCLS guideline for susceptibility testing of imipenem versus enterococci. Moreover, there are no statements to indicate that in vitro susceptibility results for other antimicrobial agents can be used to p...

The modulating effect of N-acetylcysteine (NAC) on the activity of different antibiotics has been studied in Pseudomonas aeruginosa. Our results demonstrate that, in contrast to previous reports, only the activity of imipenem is clearly affected by NAC. MIC and checkerboard determinations indicate that the NAC-based modulation of imipenem activity is dependent mainly on OprD. SDS-PAGE of outer ...

In a prospective, randomized, controlled trial, we compared sulbactam/cefoperazone with imipenem as empirical monotherapy for febrile, granulocytopenic patients; 101 patients received sulbactam/cefoperazone (2 g/4 g every 12 hours) and 102 patients received imipenem (500 mg every 6 hours). Documented infections were present in 40% of patients treated with sulbactam/cefoperazone (40 of 101) and ...

BO-2727 is a new injectable carbapenem antibiotic with broad-spectrum, potent antibacterial activity. The in-vitro and in-vivo antibacterial activities of BO-2727 were compared with those of meropenem, imipenem and biapenem. BO-2727 was four- to eight-fold more active in vitro than meropenem, imipenem and biapenem against methicillin-resistant Staphylococcus aureus, inhibiting more than 90% of ...

OBJECTIVES The primary objective of this pilot study was to investigate whether the therapeutic drug monitoring of imipenem could be performed with spent effluent instead of blood sampling collected from critically ill patients under continuous renal replacement therapy. METHODS A prospective open-label study was conducted in a real clinical setting. Both blood and effluent samples were colle...

Imipenem and its renal dehydropeptidase I inhibitor, cilastatin, were coadministered intravenously in a 1:1 ratio to 30 newborns. Five infants each received single doses of 10, 15, or 20 mg/kg of both drugs. Concentrations in plasma were proportional to the administered dose, and cilastatin achieved consistently higher concentrations than did equivalent doses of imipenem because of its smaller ...