When discussing local treatment modalities, physicians often quip that there can be no blind surgeons, suggesting that an inherent advantage to surgery is the ability to precisely visualize the target. Advances in radiation therapy (RT) technology over the years have significantly improved the radiation oncologists’ abilities to precisely sculpt high-dose radiation to a variety of targets, simu...

Synopsis:Over the past years, MR image guided radiation therapy has been developed. With development of MR-LINAC technology, it became possible to acquire high-field 1.5T image. High quality improved visualization both target and OAR compared CBCT. Furthermore, online adaptive planning system advanced. So that responds immediately changes in tumor position, shape biology. This presentation will...

The challenges of lung cancer radiotherapy are intra/inter-fraction tumor/organ anatomy/motion changes and the need to spare surrounding critical structures. Evolving radiotherapy technologies, such as four-dimensional (4D) image-based motion management, daily on-board imaging and adaptive radiotherapy based on volumetric images over the course of radiotherapy, have enabled us to deliver higher...

No signifi cant relationship exists between the authors and the companies/organizations whose products or services may be referenced in this article. Introduction Skeletal metastases are common in many types of cancer, and their incidence varies with the primary site. The majority of patients with skeletal metastases experience pain; nevertheless, modern sophisticated imaging and improved asses...

background: medical image interpolation is recently introduced as a helpful tool to obtain further information via initial available images taken by tomography systems. this information may be useful for better diagnosis of possible lesions or better tumor delineation at radiation treatment. to do this, deformable image registration algorithms are mainly utilized to perform image interpolation ...

PurposeRadiation-induced pulmonary fibrosis (RIPF) is a long-term side effect of thoracic radiation therapy. Hypoxia-induced vascular endothelial mesenchymal transition (EndMT) can occur during the development RIPF. Here, we examined direct contribution HIF-1? (EC-HIF1?) on RIPF.Methods and MaterialsAn inducible Cre-lox-mediated Hif1a deletion mouse line was used to evaluate potential inhibitio...

Cancer control and toxicity outcomes are the mainstay of evidence-based medicine in radiation oncology. However, radiotherapy is an intricate therapy involving numerous processes that need to be executed appropriately in order for the therapy to be delivered successfully. The use of image-guided radiation therapy (IGRT), referring to imaging occurring in the radiation therapy room with per-pati...