The JAK-STAT pathway mediates signal transduction evens downstream of several cytokine receptors, which are involved in the pathological processes allergic, autoimmune and inflammatory diseases, therefore JAK inhibition is a promising therapeutic strategy for skin diseases. Here we developed novel small molecule pan-JAK inhibitor, MDI1228, investigated its vivo effect on development inflammatio...

Abstract Clearance of infection with Plasmodium spp. requires both antibody and Th1-type responses. While Th1-like cells control the peak in P. chabaudi infection, however specific IgG is delayed. Both Tfh GC-Tfh can promote antibodies long-lived plasma to fully clear infection. numbers remain stable throughout while Th1/Tfh hybrid (IFN-g +/IL-21 +CXCR5 int) expand. Testing if triple cytokine r...

This study aimed to investigate the efficacy and the underlining mechanism of aspirindesensitization among patients with Aspirin Exacerbated Respiratory Disease (AERD). Thirtyeightpatients, who had undergone an aspirin challenge test and were diagnosed as havingAERD, were engaged in a double-blind randomized clinical trial. They were divided into twogroups—an active group of patients who went t...