نتایج جستجو برای: il 15
تعداد نتایج: 627023 فیلتر نتایج به سال:
Introduction: Osteoprotegerin (OPG), Interleukin-15 (IL-15), and Growth/Differentiation Factor-15 (GDF-15) are all proven to take part in the processes associated with colorectal carcinoma (CRC) including tissue remodeling, inflammation modulation, metastasis. Aim of study: To investigate concentrations GDF-15, OPG IL-15 tumor margin tissues CRC relation clinicopathological features patients. M...
IL-15, a T cell growth factor, has been linked to exacerbating autoimmune diseases and allograft rejection. To test the hypothesis that IL-15-deficient (IL-15-/-) mice would be protected from T cell-dependent nephritis, we induced nephrotoxic serum nephritis (NSN) in IL-15-/- and wild-type (IL-15+/+) C57BL/6 mice. Contrary to our expectations, IL-15 protects the kidney during this T cell-depend...
Celiac disease (CD) is an autoimmune inflammatory disease with a relatively high prevalence especially in the western hemisphere. A strong genetic component is involved in the pathogenesis of CD with virtually all individuals that develop the disease carrying HLA-DQ alleles that encode specific HLA-DQ2 or HLA-DQ8 heterodimers. Consumption of cereals rich in gluten triggers a chronic intestinal ...
IL-15 operates via a unique mechanism termed transpresentation. In this system, IL-15 produced by one cell type is bound to IL-15Rα expressed by the same cell and is presented to apposing cells expressing the IL-15Rβ/γC complex. We have shown that administering soluble IL-15Rα complexed with IL-15 can greatly enhance IL-15 activity. We now show that the naive CD8 T cell response to exogenous IL...
مقدمه: تمرین های ورزشی مقاومتی سبب افزایش توده ی عضلانی، قدرت و عملکرد عضلات در دیابتیها میشوند. سایتوکاین اینترلوکین-15 (15-il) به عنوان یک فاکتور آنابولیک برای عضله ی اسکلتی عمل می نماید. هم چنین، 15-il میتواند سوخت و ساز محیطی گلوکز را تنظیم کند. هدف پژوهش حاضر، بررسی اثر تمرین های مقاومتی مزمن بر بیان و پروتئین 15-il عضلات اسکلتی در موشهای صحرایی دیابتی بود. مواد و روشها: موش...
IL-15 shares many activities with IL-2 on stimulating lymphocytes, hematopoietic progenitor cells, and macrophages. However, the role of IL-15 in osteoclastogenesis has not been elucidated. The recent finding of abundant IL-15 in rheumatoid arthritis synovial fluids suggested a possible role for this cytokine in the pathological destruction of bone and prompted us to determine whether IL-15 sti...
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