BACKGROUND Early drug intervention in childhood disorders aims to maximize individual potential in the short- and long-term. Consistently, juvenile exposure to psychostimulants, such as methylphenidate (MPH), reduces risk for substance use in animals and sub-populations of individuals with attention deficit hyperactivity disorder (ADHD). We investigated the effects of MPH on brain plasticity vi...

Objective: The present work is designed to synthesise some isomeric new series of Quinazoline-4-one/4-thione derivatives, based on the pharmacophoric model of central nervous system (CNS) activity by structural modifications retaining the essential structural features for the activity and evaluated for their anticonvulsant and CNS depressant properties. Methods: A series of 7-chloro-3-[substitu...

AIMS Arachidonic acid (AA) and its metabolites, prostaglandins (PG) are known to be involved in regulation of vascular homeostasis including vascular tone and vessel wall tension, but their potential role in Hypoxic pulmonary vasoconstriction (HPV) remains unclear. In this study, we examined the effects of AA and PGE2 on the hypoxic response in isolated rat intrapulmonary arteries (IPAs). MET...

In this dissertation, a suite of inversion-based feedforward-feedback control techniques are developed and applied to achieve high speed AFM imaging. In the last decade, great efforts have been made in developing the inversion-based feedforward control as an effective approach for precision output tracking. Such efforts are facilitated by the fruitful results obtained in the stable-inversion th...

http://dx.doi.org/10.1016/j.engstruct.2014.10.028 0141-0296/ 2014 Elsevier Ltd. All rights reserved. ⇑ Corresponding author at: EPFL ENAC IIC EESD, GC B2 484 (Bâtiment GC), Station 18, 1015 Lausanne, Switzerland. E-mail addresses: [email protected] (J.P. Almeida), [email protected] (A.A. Correia), [email protected] (R. Pinho). 1 Address: LNEC-DE/NESDE, Av. do Brasil 101, 1700-066 Lisbon, Po...

The mechanisms of target cell recognition and producer cell self-protection (immunity) are both important yet poorly understood issues in the biology of peptide bacteriocins. In this report, we provide genetic and biochemical evidence that lactococcin A, a permeabilizing peptide-bacteriocin from Lactococcus lactis, uses components of the mannose phosphotransferase system (man-PTS) of susceptibl...

OBJECTIVE To evaluate the efficacy of Profluss® on prostatic chronic inflammation (PCI). MATERIALS AND METHODS We prospectively enrolled 168 subjects affected by LUTS due to bladder outlet obstruction submitted to 12 cores prostatic biopsy for suspected prostate cancer + 2 cores collected for PCI valuation. First group consisted of 108 subjects, with histological diagnosis of PCI associated w...

BACKGROUND & OBJECTIVES Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related deaths after lung carcinoma. The aim of this study was to understand the difference in clinicopathological behaviours and prognosis of gastric cancer in patients from China and Japan. METHODS Paraffin-fixed tissue samples of gastric cancer were collected retrospectively from ...

This note is motivated by results in [1, 8] about global relations between the invasion percolation cluster (IPC) and the incipient infinite cluster (IIC) on regular trees and on two dimensional lattices, respectively. Namely, that the laws of the two objects are mutually singular, and, in the case of regular trees, that the IIC stochastically dominates the IPC. We prove that on two dimensional...

We performed a clinical pathological study of conventionally resected superficial esophageal carcinomas since this type of lesion has been increasing, in order to develop criteria of determination for therapeutic strategies. Pathological studies were performed on specimens obtained by radical surgical resection in 133 cases of superficial esophageal cancer. Evaluation was performed in terms of ...