Recently, cholesterol was identified as a physiologically important nutrient for Mycobacterium tuberculosis survival in chronically infected mice. However, it remained unclear precisely when cholesterol is available to the bacterium and what additional bacterial functions are required for its metabolism. Here, we show that the igr locus, which we previously found to be essential for intracellul...

We report on results from a 2003 February INTEGRAL observation of the black hole candidate (BHC) 4U 1630–47 and the high energy sources in the Norma Region of the Galaxy and on RXTE and radio observations of 4U 1630–47. To date, there have been 38 new or previously poorly studied sources found by INTEGRAL (the “IGR” sources), and 15 of the IGR sources are in the field of view of our observation...

B lymphocytes are involved in inflammation and are related to insulin resistance in obesity and type 2 diabetes (T2D). This study investigated the phenotype and frequency of B-lymphocyte subsets in subjects recently diagnosed with T2D (n = 60), impaired glucose regulation (IGR, n = 73), and normal glucose tolerance (NGT, n = 169) by flow cytometry. T2D subjects had an increased percentage of CD...

The aim of this work was to establish the prevalence of overweight and obesity and its associated comorbidities in a Chinese population older than 20 years of age. A group of 2776 randomly selected adults (20-94 years of age) living in the Huayang Community in Shanghai, China, were investigated between 1998 and 2000. Body weight, height, waist and hip circumferences and blood pressure were meas...

Supergiant fast X-ray transients are a new class of high mass X-ray binaries recently discovered with INTEGRAL. Hours long outbursts from these sources have been observed on numerous occasions at luminosities of ∼10-10 erg s, whereas their low level activity at∼10-10 erg s has not been deeply investigated yet due to the paucity of long pointed observations with high sensitivity X-ray telescopes...

Objective. The aim of this study was to evaluate sex specific differences of metabolic and clinical characteristics of treated hyperlipidemic men and women (HL-men and HL-women). Methods. In this study vascular and metabolic characteristics of 35 HL-women and 64 HL-men were assessed. In addition a sex specific analysis of metabolic and nutritional habits of HL-patients with prediabetes (HL-IGR)...

The supergiant fast X-ray transient IGR J08408–4503 was discovered by INTEGRAL on May 15, 2006, during a bright flare. The source shows sporadic recurrent short bright flares, reaching a peak luminosity of 10 erg s within less than one hour. The companion star is HD 74194, an Ob5Ib(f) supergiant star located at 3 kpc in the Vela region. We report the light curves and broad-band spectra (0.1–200...

p73, the first p53 gene homologue, encodes an array of p73 proteins including p73 alpha full-length (TAp73 alpha) and amino-truncated isoforms (Delta Np73 alpha), two proteins with opposite biological functions. TAp73 alpha can induce tumor suppressive properties, while Delta Np73 alpha antagonizes p53 as well as TAp73 in a dominant-negative manner. In human malignant neuroblasts, p53 protein i...

Most eukaryotic mRNAs are translated using a cap-dependent mechanism of translation. However, approximately 10% of mammalian mRNAs initiate translation using a cap-independent mechanism that is not well understood. These mRNAs contain an internal ribosome entry site (IRES) located in the 5' untranslated region. The cricket paralysis virus (CrPV) intergenic region IRES (IGR IRES) functions in ye...

Serum samples and BW were obtained from 2-yr-old beef heifers, pregnancy with either single (SF, n = 12) or twin (TF, n = 7) fetuses, at 7-d intervals from d 190 of gestation until calving. Serum insulin-like growth factor I (IGF-I) concentrations of SF heifers gradually declined from d 190 (69.9 +/- 1.0 ng/ml) to d 263 (55.6 +/- .8 ng/ml), then exhibited a slight increase by d 277 (63.4 +/- 1....