Abstract The microbiome has emerged as a contributor to type 1 diabetes (T1D), but how interactions between the and mucosal immune system lead or prevent T1D is not clear. Previously, we found that deletion of B cell signaling protein Bruton’s Tyrosine Kinase (BTK) selectively eliminates autoreactive cells autoantibodies, preventing development. However, discovered this disease protection micro...

The immunoglobulin A (IgA) is produced to defend mucosal surfaces from environmental organisms, but host defenses against the very heavy load of intestinal commensal microorganisms are poorly understood. The IgA against intestinal commensal bacterial antigens was analyzed; it was not simply “natural antibody” but was specifically induced and responded to antigenic changes within an established ...

The biological functions of immunoglobulin (Ig)A antibodies depend primarily on their interaction with cell surface receptors. Four IgA receptors are presently characterized. The FcalphaRI (CD89) expressed by myeloid cells selectively binds IgA1 and IgA2 antibodies, whereas the poly-IgR, Fcalpha/muR, and asialoglycoprotein receptors bind other ligands in addition to IgA. IgA binding by mesangia...

IgA myeloma proteins of kappa- and lambda-types were isolated from two patients. These were used to produce and purify anti-idiotype antibodies of both broad (myeloma-related) and narrow (individual myeloma) specificities. The anti-idiotype antibodies were conjugated with fluorochromes and used as immunofluorescent probes to trace in the patients clonal expansion at different levels of B-cell d...

Effects of transforming growth factor beta (TGF-beta) on IgA production by LPS-stimulated B cells have been studied. TGF-beta itself could augment polyclonal IgA production in concomitant inhibition of polyclonal IgM and IgG1 production. Furthermore, TGF-beta and IL-5 additively augmented IgA production. TGF-beta exerted its activity early in the culture (by 2 d in a 5-d culture) and IL-5 was r...

transient hypogammaglobulinemia (thi) of infancy is a common primary immunodeficiency usually resolves by 3 years of age. in this study, clinical, immunological data and outcome of 101 retrospectively diagnosed thi patients were evaluated. majority of them suffered from recurrent respiratory infections (70.3%). initial igg, igm and iga levels were 446.7±121.5, 67.5±32.8, and 25.6±16.8 mg/dl, re...

BACKGROUND Whooping cough is a respiratory disease caused by Bordetella pertussis, which induces mucosal IgA antibodies that appear to be relevant in protection. Serum IgA responses are measured after pertussis infection and might provide an additional role in pertussis diagnostics. However, the possible interfering role for pertussis vaccinations in the induction of serum IgA antibodies is lar...

Blinatumomab has shown efficacy in B-cell malignancies. Rapid clearance of peripheral B cells has been demonstrated, resulting in sustained B-cell depletion throughout the treatment period. This report describes serum immunoglobulin levels during and after blinatumomab treatment in a phase 2 study in patients with minimal residual disease (MRD) of B-precursor acute lymphoblastic leukemia (ALL)....

H YPERAMYLASEMIA resulting from ectopic production of amylase by tumor tissue was first described by Weiss et aP in 1 95 1 . Since then, several cases of hyperamylasemia have been reported, especially in pulmonary and ovarian cancers.2’3 However, only one amylase-producing cell line has been established, that being from gastric carcinoma.’4 In addition, malignant plasma cells have also proved t...