common variable immunodeficiency (cvid) is a heterogeneous group of disorders characterized by hypogammaglobulinemia and an increased susceptibility to recurrent infections as well as autoimmunity and malignancies. idiopathic thrombocytopenic purpura (itp) and autoimmune hemolytic anemia (aiha) are two autoimmune disorders which may be seen in association with cvid. among 85 cvid patients, seve...

surgery on the skeleton frequently requires harvesting of autogenous bone graft from the pelvis, but this procedure often is complicated by problems. the purpose of this retrospective, comparative descriptive study was to compare the efficacy of metal-derived bioactive glass (novabone) versus autogenous iliac crest bone graft in adolescent idiopathic scoliosis surgery. the study was carried out...

bracing is the non-operative treatment of choice for adolescent idiopathic scoliosis (ais) and careful application of pads on apical segment of curve is very important for correction. control of pads` appropriate site in brace is not easy by clinical evaluation. therefore, we decided to compare results of braces which for better control of pads by radiographs, metal marker inserted around pads ...

restoration of the sagittal alignment is one of the fundamental goals in scoliosis correction surgery. having an increase in popularity of segmental spinal instrumentation, thoracic kyphosis (tk) is often sacrificed to achieve frontal and axial plane correction. patients with a lenke type 1 deformity underwent selective thoracic fusion (lowest instrumented vertebra of t12 or l1) using correctiv...

background: for the first time we tested an association between the human multidrug resistance gene 1 (mdr1) polymorphisms (snps) and idiopathic pulmonary fibrosis (ipf). several mdr1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. materials and methods: we genotyped three mdr1 polymorphisms of 48 ipf patients and 100 control subj...

background: despite the advances in medical therapy and technology, the prognosis of idiopathic pulmonary fibrosis (ipf) remains poor and the need for disease prevention based on identifying the risk factors becomes mandatory. occupational and environmental exposures were studied in several countries and found to play important role in the disease development. however, in egypt, a little attent...

Background Despite enormous progress in the understanding of human reproductive physiology, the underlying cause of male infertility remains undefined in about 50.0% of cases, which are referred to as idiopathic infertility and already affects about 5.0-7.0% of the general male population. Interlukin- 1 is a regulator that plays an important role in maintaining a safe environment for testes and...

AIM To investigate the association of glutathione S-transferase T1 (GSTT1) gene polymorphism in patients with idiopathic azoospermia or oligospermia in the northwestern China population. METHODS In the case-control study, GSTT1 genotypes were identified by multiplex polymerase chain reaction (PCR) with peripheral blood DNA samples from 78 patients with idiopathic azoospermia, 103 patients wit...

It is well established that the idiopathic mental disorders have a genetic basis. Yet, genetic mapping has not definitively identified any genetic mutation or polymorphism underlying these disorders. This review discusses the role of epigenetics in the pathogenesis of the idiopathic mental disorders. Epimutations and epigenetic polymorphisms are emphasized as being an interface between the gene...

A 30-year-old healthy man came to our hospital with complaints of red, hot, and painful upper extremities which spontaneously appeared. These manifestations worsened with exercises and heat, but were alleviated by rest and cooling of the hands. There were 2 similar previous episodes of short duration. The patient was a healthy, non-alcoholic, non-smoker with no history of using medicine. ...