Given that ligand binding is essential for the rapid internalization of epidermal growth factor receptor (EGFR), the events induced by ligand binding probably contribute to the regulation of EGFR internalization. These events include receptor dimerization, activation of intrinsic tyrosine kinase activity and autophosphorylation. Whereas the initial results are controversial regarding the role o...

Internalization of societal standards of attractiveness is known to play a role in the development of body dissatisfaction and disordered eating, and researchers are now working toward identifying factors that influence the internalization of those societal standards. The present study examined to what extent social connectedness and conformity were related to internalization. Female college st...

Internalization of the neurotrophin-Trk receptor complex is critical for many aspects of neurotrophin functions. The mechanisms governing the internalization process are unknown. Here, we report that neuronal activity facilitates the internalization of the receptor for brain-derived neurotrophic factor, TrkB, by potentiating its tyrosine kinase activity. Using three independent approaches, we s...

let $r$ be a commutative ring with identity. an ideal $i$ of a ring $r$is called an annihilating ideal if there exists $rin rsetminus {0}$ such that $ir=(0)$ and an ideal $i$ of$r$ is called an essential ideal if $i$ has non-zero intersectionwith every other non-zero ideal of $r$. thesum-annihilating essential ideal graph of $r$, denoted by $mathcal{ae}_r$, isa graph whose vertex set is the set...

in this note we consider the notion of intuitionistic fuzzy (weak) dual hyper k-ideals and obtain related results. then we classify this notion according to level sets. after that we determine the relationships between intuitionistic fuzzy (weak) dual hyper k-ideals and intuitionistic fuzzy (weak) hyper k-ideals. finally, we define the notion of the product of two intuitionistic fuzzy (weak) du...

BACKGROUND Depression symptoms and diagnoses are associated with failure to quit smoking in most studies, but not all. METHOD A new measure of internalization (i.e. symptoms of depression or anxiety, or poor mood) was created to investigate whether internalization would predict smoking cessation in 549 smokers from three randomized clinical trials with inconsistent findings. RESULTS Predict...

To investigate the role of the intracellular C-terminal tail of the rat metabotropic glutamate receptor 1a (mGlu1a) in receptor regulation, we constructed three C-terminal tail deletion mutants (Arg847stop, DM-I; Arg868stop, DM-II; Val893stop, DM-III). Quantification of glutamate-induced internalization provided by ELISA indicated that DM-III, like the wild-type mGlu1a, underwent rapid internal...

Introduction: Auger electron based radioimmunotherapy (RIT) using 111In-DOTA-trastuzumab (111In-DOTA-antiHer2) feasibility was studied in vitro on a HER2/neu positive cell line, SkBr3. Methods:111In-DOTA-antiHer2 was prepared according to the optimized conditions followed by quality control tests including radioch...

The purpose of this article is to analyze the impact internalizing ideal body portrayed by media drive for thinness. Previous researches directly estimate effect size mass exposure dissatisfaction with result small size. This meta-analysis considers cognitive dimension in image evaluation which individuals do, and thus taking internalization after as one variables variable articles used researc...

Although G protein-coupled receptor (GPCR) internalization has long been considered as a major aspect of the desensitization process that tunes ligand responsiveness, internalization is also involved in receptor resensitization and signaling, as well as the ligand scavenging function of some atypical receptors. Internalization thus contributes to the diversity of GPCR-dependent signaling, and i...