نتایج جستجو برای: ich

تعداد نتایج: 7722  

Journal: :The Tohoku journal of experimental medicine 2013
Jia Yin Tian-Ming Lü Guang Qiu Rui-Yu Huang Min Fang Yuan-Yuan Wang Duan Xiao Xiao-Jia Liu

Intracerebral hemorrhage (ICH) is a devastating disorder associated with high morbidity and mortality. ICH results in the formation of hematoma that affects not only the primary site of injury but also the remote regions. In fact, hematoma can extend via perivascular spaces (also called Virchow-Robin spaces, VRS) and perineurium in an animal model of ICH. In the present study, we used magnetic ...

Journal: :Annals of neurology 2003
Christopher Power Scot Henry Marc R Del Bigio Peter H Larsen Dale Corbett Yumi Imai Voon Wee Yong James Peeling

Intracerebral hemorrhage (ICH) is characterized by parenchymal hematoma formation with surrounding inflammation. Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of neurological diseases defined by inflammation and cell death. To investigate the expression profile and pathogenic aspects of MMPs in ICH, we examined MMP expression in vivo using a collagenase-induced rat m...

Journal: :Stroke 2010
Sheryl Martin-Schild Karen C Albright Hen Hallevi Andrew D Barreto Maria Philip Vivek Misra James C Grotta Sean I Savitz

BACKGROUND AND PURPOSE Cocaine is a cause of intracerebral hemorrhage (ICH), but there are no large studies that have characterized the location, pathology, and outcome of patients with cocaine-associated ICH. METHODS We performed a retrospective analysis of all patients admitted to our stroke service from 2004 to 2007 who had nontraumatic ICH and urine drug screens positive for cocaine and c...

2018
Annalisa Scimemi

Two decades into the two thousands, intracerebral hemorrhagic stroke (ICH) continues to reap lives across the globe. In the US, nearly 12,000 people suffer from ICH every year. Half of them survive, but many are left with permanent physical and cognitive disabilities, the severity of which depends on the location and broadness of the brain region affected by the hemorrhage. The ongoing efforts ...

2017
Roland Veltkamp Jan Purrucker

PURPOSE OF REVIEW We review the current evidence for medical and surgical treatments of spontaneous intracerebral hemorrhage (ICH). RECENT FINDINGS Therapy with hemostatic agents (e.g. factor VIIa and tranexamic acid) if started early after bleeding onset may reduce hematoma expansion, but their clinical effectiveness has not been shown. Rapid anticoagulation reversal with prothrombin concent...

Journal: :PloS one 2016
Chung-Fen Tsai Niall Anderson Brenda Thomas Cathie L M Sudlow

BACKGROUND Chinese populations have a higher proportion of intracerebral hemorrhage (ICH) in total strokes. However, the reasons are not fully understood. METHODS To assess the differences in frequency of major risk factors between ICH and ischemic stroke (IS) in Chinese versus white populations of European descent, we systematically sought studies conducted since 1990 that compared frequency...

Journal: :Acta neurochirurgica. Supplement 2011
Anatol Manaenko Hank Chen John H Zhang Jiping Tang

Intracerebral hemorrhage (ICH) is the most devastating type of stroke. It is characterized by spontaneous bleeding in brain parenchyma and is associated with a high rate of morbidity and mortality. Presently, there is neither an effective therapy to increase survival after intracerebral hemorrhage nor a treatment to improve the quality of life for survivors. A reproducible animal model of spont...

Journal: :Stroke 2007
Timothy D Ardizzone Xinhua Zhan Brad P Ander Frank R Sharp

BACKGROUND AND PURPOSE The mechanisms by which intracerebral hemorrhages produce changes of blood flow and metabolism, cell death, and behavioral abnormalities are complex. In this study, we begin to test the hypothesis that intracerebral hemorrhage activates Src kinases that phosphorylate other molecules to produce cell injury and behavioral deficits after intracerebral hemorrhage (ICH). MET...

2015
Ying Zhu Jia-Lu Wang Zhi-Yi He Feng Jin Ling Tang Kandiah Jeyaseelan

BACKGROUND AND PURPOSE Perihematomal edema (PHE) contributes to secondary brain damage and aggravates patient outcomes after intracerebral hemorrhage (ICH). MicroRNAs (miRNAs) are stable in circulation, and their unique expression profiles have fundamental roles in modulating vascular disease. The objective of this study was to test the hypothesis that altered miRNA levels are associated with P...

Journal: :Stroke 2013
William J Devan Guido J Falcone Christopher D Anderson Jeremiasz M Jagiella Helena Schmidt Björn M Hansen Jordi Jimenez-Conde Eva Giralt-Steinhauer Elisa Cuadrado-Godia Carolina Soriano Alison M Ayres Kristin Schwab Sylvia Baedorf Kassis Valerie Valant Joanna Pera Andrzej Urbanik Anand Viswanathan Natalia S Rost Joshua N Goldstein Paul Freudenberger Eva-Maria Stögerer Bo Norrving David L Tirschwell Magdy Selim Devin L Brown Scott L Silliman Bradford B Worrall James F Meschia Chelsea S Kidwell Joan Montaner Israel Fernandez-Cadenas Pilar Delgado Steven M Greenberg Jaume Roquer Arne Lindgren Agnieszka Slowik Reinhold Schmidt Daniel Woo Jonathan Rosand Alessandro Biffi

BACKGROUND AND PURPOSE Previous studies suggest that genetic variation plays a substantial role in occurrence and evolution of intracerebral hemorrhage (ICH). Genetic contribution to disease can be determined by calculating heritability using family-based data, but such an approach is impractical for ICH because of lack of large pedigree-based studies. However, a novel analytic tool based on ge...

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