Immune checkpoint blockade (ICB) therapies, such as immune inhibitors against programmed death ligand-1 (PD-L1), have not been successful in treating patients with pancreatic ductal adenocarcinoma (PDAC). Despite the critical role of PD-L1 various types cancers, regulatory mechanism expression on cell surface PDAC is poorly understood. Therefore, uncovering potential modulators localisation may...

Accurate Noctiluca scintillans bloom (NSB) recognition from space is of great significance for marine ecological monitoring and underwater target detection. However, most existing NSB models require expert visual interpretation or manual adjustment model thresholds, which limits application in operational monitoring. To address these problems, we developed a Bloom Recognition Network (NSBRNet) ...

Background Immune checkpoint blockade (ICB) is now a mainstay of cancer therapy with success in extending the survival time several cancers, including melanoma. Still, these modalities result immune-related adverse events (irAEs), approximately 80% melanoma patients experiencing toxicity. IrAEs can lead to treatment discontinuation, contributing mortality. In addition, one uncommon irAE high mo...

Tumour mutation burden (TMB) is a biomarker for cancer immune checkpoint blockade (ICB) response, and signatures provide “life history” of tumour evolution. Researchers have repurposed gene panels (CGPs) to cheaply estimate these parameters. The low coverage CGPs, however, may be problematic in the exploration TMB as ICB. Restriction enzyme associated DNA sequencing (RADseq) uses restriction en...

This paper describes the objectives, the tasks proposed to the participants and the associated protocols in terms of database and assessment tools of two present competitions on fingerprints and on-line signatures, the results of which will be ready for presentation at the next ICB conference. The particularity of the fingerprint competition is to be an on-line competition, for evaluation of fi...

CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about their interplay and its impact on function control. In mouse lung adenocarcinoma, we find that immunodominance established in tumors, wherein expansion predominantly driven by the antigen most stably binds MHC. T cells responding to subdominant antigens are enriched for a TCF1+ progenitor ph...

Departamento de Biologia Geral, Instituto de Ciências Biológicas – ICB, Universidade Federal de Minas Gerais – UFMG, Avenida Antônio Carlos, 6627, CEP 31270-901, Belo Horizonte, MG, Brazil Departamento de Ecologia e Biologia Evolutiva, Universidade Federal de São Carlos – UFSCar, Rodovia Washington Luiz, Km 235, CEP 13565-905, São Carlos, SP, Brazil Departamento de Hidráulica e Transportes, Cen...

Yadong Wang, François Leo, Julien Fatome, Miro Erkintalo, Stuart G. Murdoch, and Stéphane Coen 1 The Dodd-Walls Centre for Photonic and Quantum Technologies, Physics Department, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand 2 OPERA-Photonique, Université Libre de Bruxelles, CP 194/5, 50 Av. F. D. Roosevelt, B-1050 Brussels, Belgium and 3 Laboratoire Interdisciplinair...

Maria Ganzha, Marcin Paprzycki, Costin Badica and Rainer Unlandd,∗ aSystems Research Institute, Polish Academy of Sciences, Warsaw and University of Gdansk, Warsaw, Poland bSystems Research Institute, Polish Academy of Sciences, Warsaw and Management Academy, Warsaw, Poland cSoftware Engineering Department, Faculty of Automatics, Computers and Electronics, University of Craiova, Bvd.Decebal, Cr...