Abstract The development of specific antiviral compounds to SARS-CoV-2 is an urgent task. One the obstacles for requirement biocontainment because infectious must be handled in a biosafety level-3 laboratory. Replicon, non-infectious self-replicative viral RNA, could safe and effective tool evaluation. Herein, we generated PCR-based replicon. Eight fragments covering entire genome except S, E, ...

Using the idea of ic-open sets, we introduce and investigate topological qualities an ic-closure, ic-interior, ic-limit points, ic-derived, ic-border, ic-frontier, ic-exterior a set. Introduce concepts "ic-continuous mappings," "ic-open "ic-irresolute "ic-totally continuous "ic-homeomorphism," then look into some properties these mappings

Sympathetic efferent nerves are present in tendons, but their function within tendon is unknown. alpha(1)-Adrenoceptors are expressed by a variety of cell types. In the presence of norepinephrine (NE), adrenoceptors activate G(q/11) signaling pathways that subsequently increase intracellular Ca(2+) concentration ([Ca(2+)](ic)). It was hypothesized that avian tendon cells express functional adre...

PURPOSE In this study, we examined the expression of human mammaglobin (hMAM) mRNA and the protein levels in patients with breast cancer and their relationship with prognostic clinicopathological parameters. METHODS hMAM mRNA expression in leucocytes from peripheral blood samples from patients diagnosed with primary invasive breast cancer (IC), carcinoma in situ (CIS), or benign breast diseas...

Background: Early diagnosis of SARS-CoV-2 infection is essential to reduce disease spread. Rapid antigen tests have not been sufficiently evaluated in asymptomatic patients be used as massive population screening tools. Methods: Head-to-head evaluation Roche rapid test a tool adults from semi-closed community. Sensitivity, specificity and predictive values were calculated using RT-PCR refere...

OBJECTIVE Notch signalling pathways are critical for angiogenesis and endothelial cell (EC) fate; however the mechanisms regulating these processes in the inflamed joint remain to be elucidated. Here, we examine whether Notch signalling mediates vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang2)-induced vascular function. METHODS Notch-1 intracellular domain (Notch-1 IC), Not...

Cucumber mosaic virus (CMV) is one of the causal agents of viral diseases that infected mint (Mentha spp.). CMV is a member of the cucumovirus genus in  Bromoviridae family. The virus is naturally transmitted by aphids in a non-persistent manner.During  growing season 2007-2008, leaf samples from plants of mint fields with symptoms of viral disease were collected in mint fieldas in Tehran provi...

More than a decade of research in the field of thermal, motion, vibration and electromagnetic radiation energy harvesting has yielded increasing power output and smaller embodiments. Power management circuits for rectification and DC–DC conversion are becoming able to efficiently convert the power from these energy harvesters. This paper summarizes recent energy harvesting results and their pow...