Objective(s): The aim of this study was to identify the role of miR-155 in the myocardial ischemia/reperfusion (I/R) injury through targeting hypoxia-inducible factor 1-alpha (HIF-1α). Materials and Methods: We constructed rat models with myocardial I/R injury and H9C2 cell models with hypoxia/reoxygenation (H/R) damage. Anti-miR-155 and...

Motion adaptation in directionally selective tangential cells (TC) of the fly visual system has previously been explained as a presynaptic mechanism. Based on the observation that adaptation is in part direction selective, which is not accounted for by the former models of motion adaptation, we investigated whether physiological changes located in the TC dendrite can contribute to motion adapta...

Financial problems have been the subject of much research. A widely used approach in recent work on these problems is the use of fuzzy set theory, where fuzzy terms are used to model the uncertain environments. The purpose of this work is to combine the fuzzy analytic hierarchy process (AHP) with the portfolio selection problem. More specifically, the decision-making problem is to decide which ...

The descending contralateral movement detector (DCMD) is a high-performance interneuron in locusts with an axon capable of transmitting action potentials (AP) at more than 500 Hz. We investigated biophysical mechanisms for fidelity of high-frequency transmission in this axon. We measured conduction velocities (CVs) at room temperature during exposure to 10 mmol/L cadmium, a calcium current anta...

Multi-criteria analysis (MCA) is being used in the Sediment and Society project as a tool for communicating impacts, as a tool for documenting differences in interests of stakeholder groups, and as a tool for ranking complex sediment remediation alternatives. Ranking of alternatives in MCA requires impacts to be (i) standardised, and then (ii) weighted against one another. This Technical Brief ...

Many neurons, including pyramidal cells of the cortex, express a slow afterhyperpolarization (sAHP) that regulates their firing. Although initial findings suggested that the current underlying the sAHP could be carried through SK(Ca) channels, recent work has uncovered anomalies that are not congruent with this idea. Here, we used overexpression and dominant-negative strategies to assess the in...

We present attributed hierarchical port graphs (AHP) as an extension of port graphs that aims at facilitating the design of modular port graph models for complex systems. AHP consist of a number of interconnected layers, where each layer defines a port graph whose nodes may link to layers further down the hierarchy; attributes are used to store user-defined data as well as visualisation and run...

Learning-related reductions of the postburst afterhyperpolarization (AHP) in hippocampal pyramidal neurons have been shown ex vivo, after trace eyeblink conditioning. The AHP is also reduced by many neuromodulators, such as norepinephrine, via activation of protein kinases. Trace eyeblink conditioning, like other hippocampus-dependent tasks, relies on protein synthesis for consolidating the lea...

The analytic hierarchy process (AHP) provides a structure on decision-making processes where there are a limited numbers of choices but each has a number of attributes. This paper explores the use of AHP for deciding on car purchase. In the context of shopping, it is important to include elements that provide attributes that make consumer decision-making easier, comfortable and therefore, lead ...