نتایج جستجو برای: hypoxia

تعداد نتایج: 57882  

Ahmad Reza Bahrami Asieh Heirani-Tabasi Hamid Reza Bidkhori Hojjat Naderi-Meshkin Mahmood Raisolmohaddesin Mahmoud Hosseini Maliheh Hasanzadeh Maryam M. Matin Mina Shahryari Naghmeh Ahmadiankia Nasser Sanjar Moussavi

Clinical applications of mesenchymal stem cells (MSCs) rely on their capacity to home and engraft in the appropriate target tissues for a long time. Homing and engraftment capacity of these stem cells depend on the expression of Chemokines and their receptors. Ex vivo expanded MSCs exhibit homing potential when grafted to injury tissue but their homing efficiency has been observed very poor bec...

Amir Reza Jalilian, Fatemeh Bolourinovin Gholamreza Aslani Hassan Yousefnia, Kamaleddin Shafaii Mohsen Kamali-Dehghan Sedigheh Moradkhani

  Introduction: [61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu]ATSM) is a well-established hypoxia imaging tracer with simple production and significant specifity. In this work the accumulation of the tracer is studied in wild-type, necrotic and hypoxic fibrosarcoma tumors. Methods: [61Cu]ATSM was prepared u...

Christian Thomas, Ole Simon, Oliver Grauer, Petra Hundehege, Sven Meuth, Thomas Müntefering, Tobias Ruck,

TASK-3, a two-pore-domain (K2P) potassium channel, has been implicated as important regulator for the effector function and proliferation of T-cells. Interestingly, TASK-3 has also a functional impact on tumor cells. Therefore, we sought to investigate whether TASK3 modulation might have a therapeutic potential for malignant gliomas by a variety of phenotypical and functional in vitro assays mi...

Journal: :American journal of respiratory cell and molecular biology 2005
Kristin Heerlein Andreas Schulze Lorenz Hotz Peter Bärtsch Heimo Mairbäurl

Hypoxia inhibits activity and expression of transporters involved in alveolar Na reabsorption and fluid clearance. We studied whether this represents a mechanism for reducing energy consumption or whether it is the consequence of metabolic dysfunction. Oxygen consumption (JO2) of A549 cells and primary rat alveolar type II cells was measured by microrespirometry during normoxia, hypoxia (1.5% O...

2017
Eugenia Mata-Greenwood Dipali Goyal Ravi Goyal

Background : Hypoxia inducible factor 1 alpha (HIF1A) is a master regulator of acute hypoxia; however, with chronic hypoxia, HIF1A levels return to the normoxic levels. Importantly, the genes that are involved in the cell survival and viability under chronic hypoxia are not known. Therefore, we tested the hypothesis that chronic hypoxia leads to the upregulation of a core group of genes with as...

Journal: :Brain research 2000
C Rauca H Jantze M Krug

To clarify the question whether the duration of hypoxia exposure has an influence on the point in time or the strength of hypoxic preconditioning, hypoxia exposure of rats lasting 1 and 8 h was tested regarding the modification of susceptibility to acute pentylenetetrazol-induced seizures. Following the short-lasting (1 h) hypoxia, the maximum level of preconditioning action was observed 7 days...

Journal: :The Journal of experimental biology 2016
Sherry N N Du Sajeni Mahalingam Brittney G Borowiec Graham R Scott

Many fish encounter hypoxia in their native environment, but the role of mitochondrial physiology in hypoxia acclimation and hypoxia tolerance is poorly understood. We investigated the effects of hypoxia acclimation on mitochondrial respiration, O2kinetics, emission of reactive oxygen species (ROS), and antioxidant capacity in the estuarine killifish ( ITALIC! Fundulus heteroclitus). Killifish ...

Journal: :Frontiers in Immunology 2021

Background Imbalanced nutritional supply and demand in the tumor microenvironment often leads to hypoxia. The subtle interaction between hypoxia immune cell behavior plays an important role occurrence development. However, functional relationship remains unclear. Therefore, we aimed investigate effect of on intestinal microenvironment. Method We extracted names hypoxia-related genes from Gene S...

Journal: :Respiratory Research 2021

Abstract Background COVID-19 pneumonia has been associated with severe acute hypoxia, sepsis-like states, thrombosis and chronic sequelae including persisting hypoxia fibrosis. The molecular response pathway such pathologies our recent observations on anti-hypoxic anti-inflammatory effects of whole aqueous extract Adhatoda Vasica (AV) prompted us to explore its relevant preclinical mouse models...

2014
Angela Yuen Begoña Díaz

Intratumoral hypoxia is a common feature of solid tumors. Recent advances in cancer biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but also plays an active role in promoting tumor progression, malignancy, and resistance to therapy. Hypoxia signaling is mediated by the hypoxia-inducible factors (HIFs), which are not only stabilized under hypoxia, but also b...

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