Background: Fanconi anemia (FA) is a rare, autosomal recessive (AR) and multifactorial disorder. A high prevalence of FA observed in Iran is perhaps due to the high rate of consanguineous marriages. This study investigates the extent of short stature in patients with FA, the frequency of hypothyroidism in FA and the correlation between height and hypothyroidism. Methods: Eighteen patients with ...

hypothyroidism is one of the problems that can cause severe growth and developmental defects in children and infants. by using anticonvulsive drugs (phenobarbital, carbamazepine, navalproate , and phenytoin), liver microsomal enzymes will be increased and will lead to hypothyroidism in infants because of increasing metabolism of t3, and t4 by liver. the purpose of this study was to evaluate the...

Background: It is challenging to measure BMI accurately in population studies because it an expensive and time-consuming task. As a result, subjectively measured BMI, calculated from self-reported height weight, which we know be inaccurate, often used. The purpose of this study determine whether using different, subjectiv...

OBJECTIVE Melanocortin-4 receptor (MC4R) mutations are the most common known cause of monogenic obesity. Data regarding MC4R mutations in Turkish subjects are limited. To determine the prevalence of MC4R mutations in a group of Turkish morbid obese children and adolescents. METHODS MC4R was sequenced in 47 consecutive morbidly obese children and adolescents (28 girls and 19 boys, aged 1-18 ye...

INTRODUCTION Excess bodyweight is known to be associated with many medical disorders which can be disqualifying for aviators. The actual prevalence of these conditions and associations with BMI in U.S. airmen has not been previously defined. This project explores overweight and obesity in valid holders of U.S. aeromedical certificates as of November 2003. METHODS A de-identified database of a...

OBJECTIVE To determine the prevalence of endocrinopathies, neuroradiographical findings, and growth derangements in young children with optic nerve hypoplasia (ONH). STUDY DESIGN A prospective observational study examined the prevalence of endocrinopathies at study enrollment and growth patterns in children with ONH. Subjects (n = 47, mean +/- SD 15.2 +/- 10.6 months) were followed until 59.0...

Subclinical hypothyroidism (SCH) is a common condition that is often observed without therapy. However, no evidence-based recommendation exists with regards to how patients with untreated SCH should be monitored. Monitoring involves regular assessment of symptoms and signs of hypothyroidism (HYPO) and biochemical tests of thyroid function. An important question when repeated tests of thyroid fu...

Introduction: Congenital hypothyroidism is the most common endocrine disease and is a major cause of preventable mental retardation. In most cases, it seems quite natural born at birth with delayed diagnosis, complications will cause irreparable brain. Now almost all industrialized countries and many developing countries the newborn screening program to systematically do. Khorasan Province neon...