Anaplastic large T-cell lymphoma (ALCL) is frequently associated with the t(2;5)(p23;q35). Here, we report a case of ALCL with an atypical translocation of t(2;5)(p24;q13) and other complex translocations. This complex abnormal karyotype may result in chemotherapy resistance and a poor outcome. Interestingly, a hypophyseal tumor was detected simultaneously by magnetic resonance imaging in this ...

A 14 year-old patient was admitted because of a history of polyuria and polydipsia. A diagnosis of central diabetes insipidus (CDI) accompanied by growth hormone (GH) and gonadotropin deficiency was made. Hypophyseal magnetic resonance imaging (MRI) of the patient demonstrated isolated pituitary stalk enlargement. Although GH deficiency and gonadotropin deficiency were transient, CDI was persis...

OBJECTIVE It has been suggested that the high prevalence of subnormal free testosterone concentrations, along with low or inappropriately normal gonadotropins in men with type 2 diabetes, may be the result of an increase in plasma estradiol concentrations secondary to an increase in aromatase activity in the adipose tissue that leads to the suppression of the hypothalamo-hypophyseal-gonadal axi...

Considering the close analogy between the insect median neurosecretory cell (m.n.c.)/ corpus cardiacum (c.c.) complex, and the vertebrate hypothalamo-hypophyseal system (Scharrer & Scharrer, 1944), few studies have been made on the possible hormonal control of water metabolism in insects. In fact, our present knowledge of this aspect is confusing and, in some cases, contradictory (Wall & Ralph,...

Experiments are reported on the induction of mammary carcinoma in intact, mammary tumor agent (MTA)-free female ( 9 020 x a" DBAf)Fi mice by single and multiple (4) prolactinproducing hypophyseal isografts in the kidney. Tumor incidences varying between 67 and 88 % were recorded in the treated groups as against 2% in virgin controls. Identical treatment of intact and castrated males proved tota...