Sjögren's syndrome is mainly affects the exocrine glands. Patients usually complain of persistent dryness of the mouth and eyes. However, nonexocrine organs such as the kidneys are often affected in these patients. Distal renal tubular acidosis (dRTA) and interstitiel nephritis are common in Sjögren's syndrome. Nonetheless, severe hypokalemia and paralysis secondary to dRTA are unusual initial ...

OBJECTIVE To report an unusual involvement of focal distal muscles but not proximal muscles in a patient with hypokalemic periodic paralysis (hypoPP). CLINICAL PRESENTATION AND INTERVENTION A middle-aged woman presented with episodic weakness of the bilateral thumbs lasting for 2 years. Hypokalemia and a left adrenal mass were subsequently found. Her weakness subsided after surgical removal o...

We report the discovery of quasi-periodic oscillations (QPOs) at roughly 187 and 150 Hz in the X-ray intensity of X-ray nova XTE J1859+226. The source was observed during a recent outburst with the Rossi X-Ray Timing Explorer. Besides these high-frequency QPOs, we have also detected QPOs (and sometimes their harmonics) at 6-7 Hz and significant broadband variability at low frequencies. These pr...

In a patient who had a sudden onset of bilateral diaphragmatic paralysis after forceful neck manipulation complete, though gradual, recovery in lung function and transdiaphragmatic pressures was seen over three years. This is a previously unrecognised risk of neck osteopathy.

A case ofyoung (20 years old) nale presenting with dranratic onset ofweakness in all the linùs is presented. Patient had three such episodes in the past 2 years lasting for 4-6 hrs. There was no fanùly history of such weakness. A diagnosis of hypolcnlaettùc periodic paralysis was made. Patient was given intravenous potassiun4 intproved considerably and put on acetazolailûde prophylafis. The cas...

Hypokalemic periodic paralysis is one of the most distinctive complications of hyperthyroidism and occurs in 8 to 34% of men and 0.2% of women with thyrotoxicosis in Asia. It is also complicated by other diseases with potassium defi ciency such as Bartter’s syndrome, Cushing’s syndrome, and Gitelman’s syndrome. Generally, hypokalemic periodic paralysis with hyperthyroidism is diagnosed by asses...

A family with hypokalemic periodic paralysis (HypoPP) and motor neuron degeneration is reported. In conjunction with HypoPP, the index patient developed progressive muscle atrophy. The calcium channel gene CACNA1S showed a mutation encoding p.R528H, which has been related previously to HypoPP. We propose that CACNA1S mutations may comprise a previously unrecognized genetic risk factor in a grea...