INTRODUCTION Psychopathological origins of personally distressing, hypoactive sexual desire disorder (HSDD) in women are unknown, but are generally attributed to an inhibitory neural regulator, serotonin (5-HT). Flibanserin, a 5-HT(1A) agonist and 5-HT(2A) antagonist, shows promise as a treatment for HSDD. AIM To test the hypothesis that female marmoset sexual behavior is enhanced by flibanse...

Logic would suggest that women with low sexual desire do not acquire sexually transmitted infections. However, this may not be the case. Until recently, it has been considered that sexual activity in women is initiated by desire, which produces arousal. This leads to orgasm and resolution. 2 In practice, sexual desire and arousal are not isolated psychological and physiological states but inter...

Flibanserin is a novel antagonist small molecule to treat the hypoactive sexual desire disorder (HSDD) in the premenopausal women. The present article is related to the structural and electronic properties study and docking analysis of the title compound with 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor. To access these aims, the molecular structure of the said compound was optimized usin...

INTRODUCTION Recently, there has been much discussion in the literature about how to determine the meaningfulness of results generated from a patient-reported outcome measure. A number of reviews have shown that there are two main approaches: anchor- and distribution-based approaches for determining the minimum important difference (MID) for a new measure. There are issues with calculating an M...

BACKGROUND Regardless of the relationship between aging and sexual dysfunction, most adults continue to be sexually active in their later years. Conditions such erectile dysfunction or hypoactive sexual desire disorder present one of many barriers to maintain a healthy sex life. OBJECTIVE This article links the concurrence between the social, cultural, political, and economic changes on a wor...

In recent decades, women are increasingly contact the doctors with problems of hypoactive sexual desire disorders (HSDD). Female libido is considered as one important indicators quality life, health. Therapy HSDD difficult due to insufficient knowledge by both complex, multiple pathogenetic mechanisms reduction and modern therapeutic approaches. this article, female from point view biopsychosoc...

BACKGROUND The aim of this study was to determine the cumulative prevalence rate of every sexual dysfunctions (SDs) in Iranian population. METHODS We searched international database such as: PubMed/Medline, Scopus, PsychNET, and Scholar Google and Iranian database such as Iran Psych, IranDoc, IranMedex, and SID. Search duration was between 1990 and 2013. RESULTS From 449 articles were retri...

INTRODUCTION The complex condition of the menopause is experienced by all women going through the physical and emotional changes associated with ovarian sexual hormones loss. It may impact directly on their physical and mental health. AIM The complexity of this condition makes it necessary to accumulate large bodies of data to define the patterns and trends in its evaluable manifestations. To...