conclusions a review of the literature on the use of hypnotic drugs in patients with liver dysfunction showed that some hypnotic drugs used during anesthesia could be safely used in patients with impaired liver function. in these patients, certain drugs should be used with caution. results anesthesia should be performed with caution in patients with hepatic dysfunction and drugs with long half-...

OBJECTIVE Sleeplessness is the most common sleep disorder. In this study the hypnotic effect of the hydro-alcoholic extract (HAE) of Perovskia abrotanoides Karel. and its water fraction (WF), ethyl acetate fraction (EAF) and n-butanol fraction (NBF) were studied in mice. MATERIALS AND METHODS The test compounds were administered intraperitoneally to mice 30 min before the administration of so...

BACKGROUND Our previous reports demonstrated that genetic deletion of μ-opioid receptor has no influence on the anaesthetic and antinociceptive effects of nitrous oxide (N2O) in mice, and that an antagonist selective for κ-opioid receptor (KOP), but not that selective for δ-opioid receptor, suppresses the antinociceptive effect of N2O. However, it is not known whether genetic deletion of KOP af...

Hypnosis can profoundly alter sensory awareness and cognitive processing. While the cognitive and behavioral phenomena associated with hypnosis have long been thought to relate to attentional processes, the neural mechanisms underlying susceptibility to hypnotic induction and the hypnotic condition are poorly understood. Here, we tested the proposal that highly hypnotizable individuals are part...

OBJECTIVE To compare how newly initiated treatment with benzodiazepines, Z-hypnotics or both associates with the reception of disability pension among 40,661 individuals of a working age. DESIGN Prescription register study. SETTING Norwegian nationwide prescriptions socio-economic and disability status data. METHODS Cox regression analyses. SUBJECTS New benzodiazepine or Z-hypnotic user...

This project aimed to assess the consistency of hypnotizability over repeated assessments when measured by Stanford Hypnotic Susceptibility Scale: Form C (SHSS:C), and Elkins Hypnotizability Scale (EHS) contrast score distribution pleasantness these scales. University students were administered either SHSS:C or EHS twice with a one-week delay separate experimenters. Test–retest reliability was ...

Determination of hypnotizability is important, before prescribing any hypnotic treatment. Existing methods for measuring the level of hypnotic susceptibility are subjective, with some problems. In this study, a feature based on EEG weighted regional frequency was introduced, which can characterize the level of the subject's hypnotizability objectively. The ability of this feature for making a s...

Rats were made tolerant to the hypnotic effects of the alpha-2 adrenergic agonist dexmedetomidine by a 7- or 14-day continuous systemic administration of the same, and the ability of nifedipine to reverse dexmedetomidine tolerance was assessed. Acute administration of nifedipine (10 mg/kg i.p.) restored the hypnotic response to dexmedetomidine in the alpha-2 tolerant rats. Concurrent administra...

Background. The increased practice of traditional Chinese medicine (TCM) worldwide has raised concerns regarding herb-drug interactions. The purpose of our study is to analyze the concurrent use of Chinese herbal products (CHPs) among Taiwanese insomnia patients taking hypnotic drugs. Methods. The usage, frequency of services, and CHP prescribed among 53,949 insomnia sufferers were evaluated fr...

This article summarizes key advances in hypnosis research during the past two decades, including (i) clinical research supporting the efficacy of hypnosis for managing a number of clinical symptoms and conditions, (ii) research supporting the role of various divisions in the anterior cingulate and prefrontal cortices in hypnotic responding, and (iii) an emerging finding that high hypnotic sugge...