The scope of the problem of the management of pregnancies occurring in women with pituitary disease is indicated by the fact that 20% ofnon-pregnant women with amenorrhoea have hyperprolactinaemia and 40% of women with hyperprolactinaemia have pituitary tumours (Franks et al., 1975). We concentrate therefore on disturbance of prolactin secretion and discuss other pituitary diseases only briefly...

Hyperprolactinaemia especially affects women in reproductive age (90/100,000) but also often is diagnosed in menopause age and leads to disturbances in functioning of LH-RH neurons and, as a consequence, to a decrease of FSH and LH, which causes inhibition of oestradiol production. Prolactin is a peptide hormone, phylogenetically one of the oldest, stimulating cells of various organs, which is ...

OBJECTIVE The stimulatory and inhibitory effects of N-methyl-D-aspartic acid (NMDA) and kainic acid on prolactin (PRL) secretion have been correlated with the serum prolactin concentrations before drug administration. In the present experiments, we analysed the role of NMDA and kainic acid in PRL secretion in females with different serum concentrations of PRL. METHODS Hypoprolactinaemic femal...

The overall frequency of neurological involvement in sarcoidosis is 5% (Delaney, 1977). Infiltration of the hypothalamic-pituitary region by sarcoid granulomata may cause anterior pituitary hormonal deficiencies, hyperprolactinaemia or diabetes insipidus. Hypothalamic-pituitary dysfunction almost always occurs in a patient with widespread disease involving lungs, skin or liver (Stuart, Neelon a...