Insulin resistance (IR) and related disorders, such as T2DM, increase the risk of major depressive disorder (MDD) vice versa. Current evidence indicates that psychological stress overeating can induce chronic low-grade inflammation interfere with glutamate metabolism in MDD well insulin signaling, particularly atypical subtype. Here we first review interactive role inflammatory processes develo...

Although hypothalamic hyperphagia was described and named 25 years ago,: the nature of this phenomenon is still not clear. Presumably it is brought about by some deficiency in the systems controlling food intake. What this deficiency might be was explicitly considered by Kennedy' in the paper where he suggested that the body regulates its fat content. He had confirmed the observation of Brobeck...